Journal article
Authors list: Dumitrascu, Rio; Tiede, Henning; Eckermann, Jan; Mayer, Konstantin; Reichenberger, Frank; Ghofrani, Hossein Ardeschir; Seeger, Werner; Heitmann, Joerg; Schulz, Richard
Publication year: 2013
Pages: 247-251
Journal: Sleep Medicine
Volume number: 14
Issue number: 3
ISSN: 1389-9457
eISSN: 1878-5506
DOI Link: https://doi.org/10.1016/j.sleep.2012.11.013
Publisher: Elsevier
Objectives: Pilot studies have described the occurrence of sleep apnea in patients with precapillary pulmonary hypertension (PH). However, there are no data on the prevalence of sleep-related breathing disorders in larger patient cohorts with PH. Methods: 169 patients with a diagnosis of PH confirmed by right heart catheterisation and clinically stable in NYHA classes II or III were prospectively investigated by polygraphy (n = 105 females, mean age: 61.3 years, mean body mass index: 27.2 kg/m(2)). Recruitment was independent of sleep-related symptoms and the use of vasodilator drugs or nasal oxygen. Results: 45 patients (i.e. 26.6%) had an apnea-hypopnea-index (AHI) > 10/h. Of these, 27 patients (i.e. 16%) had obstructive sleep apnea (OSA) and 18 patients (i.e. 10.6%) had central sleep apnea (CSA). The mean AHI was 20/hour. As a polygraphy had been performed with nasal oxygen in half of the patients without evidence for sleep apnea, the frequency of CSA was probably underestimated. Patients with OSA were characterized by male gender and higher body mass index whereas, those with CSA were older and hypocapnic. Conclusions: At least every fourth patient with PH suffers from mild-to-moderate sleep apnea. Considering the anthropometric characteristics of the patients studied, the prevalence of both OSA and CSA seem to be higher in PH than in the general population. (C) 2012 Elsevier B.V. All rights reserved.
Abstract:
Citation Styles
Harvard Citation style: Dumitrascu, R., Tiede, H., Eckermann, J., Mayer, K., Reichenberger, F., Ghofrani, H., et al. (2013) Sleep apnea in precapillary pulmonary hypertension, Sleep Medicine, 14(3), pp. 247-251. https://doi.org/10.1016/j.sleep.2012.11.013
APA Citation style: Dumitrascu, R., Tiede, H., Eckermann, J., Mayer, K., Reichenberger, F., Ghofrani, H., Seeger, W., Heitmann, J., & Schulz, R. (2013). Sleep apnea in precapillary pulmonary hypertension. Sleep Medicine. 14(3), 247-251. https://doi.org/10.1016/j.sleep.2012.11.013
Keywords
MEN; Polygraphy; Pulmonary hypertension; Sleep apnea
