Conference paper

Publication year: 2013

Pages: S42-S46

Journal: Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis

Volume number: 131

ISSN: 0049-3848

DOI Link: https://doi.org/10.1016/S0049-3848(13)70020-3

Conference: 5th International Symposium on Women's Health Issues in Thrombosis and Haemostasis

Publisher: Elsevier

Abstract: 
In fetal/neonatal alloimmune thrombocytopenia (FNAIT), antibodies against paternal antigens present on fetal platelets are produced by the mother. These antibodies will cross the placenta and can cause thrombocytopenia of the unborn. One severe consequence of thrombocytopenia is intracranial bleeding which may lead to death or severe sequelae. FNAIT index cases in one family are usually detected at birth only since antenatal screening programmes have not been installed so far. Subsequent pregnancies of immunized mothers may require special diagnostic and prophylactic interventions, and interdisciplinary counselling and treatment involving obstetricians, pediatricians and immunohematologists may prove useful for optimized care. This short review covers pathogenesis, clinical presentation, diagnostic, and therapeutic options in FNAIT. (C) 2013 Elsevier Ltd. All rights reserved.

Harvard Citation style: Sachs, U. (2013) Fetal/neonatal alloimmune thrombocytopenia, Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis, 131, pp. S42-S46. https://doi.org/10.1016/S0049-3848(13)70020-3

APA Citation style: Sachs, U. (2013). Fetal/neonatal alloimmune thrombocytopenia. Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis. 131, S42-S46. https://doi.org/10.1016/S0049-3848(13)70020-3