Journal article

Publication year: 2013

Pages: 566-569

Journal: Clinical Chemistry

Volume number: 59

Issue number: 3

ISSN: 0009-9147

eISSN: 1530-8561

Open access status: Bronze

DOI Link: https://doi.org/10.1373/clinchem.2012.194001

Publisher: Oxford University Press

Abstract: 

BACKGROUND: The release kinetics of copeptin in patients with acute myocardial infarction (AMI) have been difficult to establish.

METHODS: We analyzed the release kinetics of copeptin inpatients with hypertrophic obstructive cardiomyopa-thy undergoing transcoronary ablation of septal hypertrophy (TASH) as a model of AMI. We included 21 consecutive patients who underwent TASH. Blood samples were collected before and at 15, 30, 45, 60, 75, 90, and 105 min, and at 2, 4, 8, and 24 h after TASH. Serum copeptin was quantified by a sandwich immunoluminometric assay.

RESULTS: All patients had copeptin concentrations below the 99th percentile at baseline. The median copeptin concentration was significantly increased at 30 min [16.0 pmol/L; interquartile range (IQR), 13.4-20.2 pmol/L], compared with the median baseline concentration (6.6 pmol/L; IQR, 5.3-8.3 pmol/L; P = 0.002). The copeptin concentration peaked 90 min after induction of myocardial infarction and returned to baseline concentrations (median, 8.2 pmol/L; IQR, 6.3-10.1) after 24 h, compared with the above baseline values (P = 0.06). Serum creatine kinase (CK) activities were significantly increased above baseline values by 1 day after TASH [median maximal postprocedural CK activity, 935.0 U/L (IQR, 545.5-1115.0 U/L); median baseline CK activity, 80.0 U/L (IQR, 63.5-109.0 U/L); P < 0.001].

CONCLUSIONS: Our results provide additional evidence that early rule-out of suspected AMI is possible by using the copeptin concentration in combination with cardiac troponin T.

Harvard Citation style: Liebetrau, C., Nef, H., Szardien, S., Doerr, O., Willmer, M., Voss, S., et al. (2013) Release Kinetics of Copeptin in Patients Undergoing Transcoronary Ablation of Septal Hypertrophy, Clinical Chemistry, 59(3), pp. 566-569. https://doi.org/10.1373/clinchem.2012.194001

APA Citation style: Liebetrau, C., Nef, H., Szardien, S., Doerr, O., Willmer, M., Voss, S., Troidl, C., Hoffmann, J., Rixe, J., Rolf, A., Hamm, C., & Moellmann, H. (2013). Release Kinetics of Copeptin in Patients Undergoing Transcoronary Ablation of Septal Hypertrophy. Clinical Chemistry. 59(3), 566-569. https://doi.org/10.1373/clinchem.2012.194001