Journalartikel

Jahr der Veröffentlichung: 2013

Seiten: 521-527

Zeitschrift: European Urology

Bandnummer: 63

Heftnummer: 3

ISSN: 0302-2838

eISSN: 1873-7560

DOI Link: https://doi.org/10.1016/j.eururo.2012.06.003

Verlag: Elsevier

Abstract: 

Background: Infection is a serious adverse effect of prostate biopsy (P-Bx), and recent reports suggest an increasing incidence.

Objective: The aim of this multinational multicentre study was to evaluate prospectively the incidence of infective complications after P-Bx and identify risk factors.

Design, setting, and participants: The study was performed as an adjunct to the Global Prevalence Study of Infections in Urology (GPIU) during 2010 and 2011. Men undergoing P-Bx in participating centres during the 2-wk period commencing on the GPIU study census day were eligible.

Outcome measurements and statistical analysis: Baseline data were collected and men were questioned regarding infective complications at 2 wk following their biopsy. The Fisher exact test, Student t test, Mann-Whitney U test, and multivariate regression analysis were used for data analysis.

Results and limitations: A total of 702 men from 84 GPIU participating centres worldwide were included. Antibiotic prophylaxis was administered prior to biopsy in 98.2% of men predominantly using a fluoroquinolone (92.5%). Outcome data were available for 521 men (74%). Symptomatic urinary tract infection (UTI) was seen in 27 men (5.2%), which was febrile in 18 (3.5%) and required hospitalisation in 16 (3.1%). Multivariate analysis did not identify any patient subgroups at a significantly higher risk of infection after P-Bx. Causative organisms were isolated in 10 cases (37%) with 6 resistant to fluoroquinolones. The small sample size per participating site and in compared with other studies may have limited the conclusions from our study.

Conclusions: Infective complications after transrectal P-Bx are important because of the associated patient morbidity. Despite antibiotic prophylaxis, 5% of men will experience an infective complication, but none of the possible factors we examined appeared to increase this risk. Our study confirms a high incidence of fluoroquinolone resistance in causative bacteria. (C) 2012 European Association of Urology. Published by Elsevier B.V. All rights reserved.

Harvard-Zitierstil: Wagenlehner, F., van Oostrum, E., Tenke, P., Tandogdu, Z., Cek, M., Grabe, M., et al. (2013) Infective Complications After Prostate Biopsy: Outcome of the Global Prevalence Study of Infections in Urology (GPIU) 2010 and 2011, A Prospective Multinational Multicentre Prostate Biopsy Study, European Urology, 63(3), pp. 521-527. https://doi.org/10.1016/j.eururo.2012.06.003

APA-Zitierstil: Wagenlehner, F., van Oostrum, E., Tenke, P., Tandogdu, Z., Cek, M., Grabe, M., Wullt, B., Pickard, R., Naber, K., Pilatz, A., Weidner, W., & Bjerklund-Johansen, T. (2013). Infective Complications After Prostate Biopsy: Outcome of the Global Prevalence Study of Infections in Urology (GPIU) 2010 and 2011, A Prospective Multinational Multicentre Prostate Biopsy Study. European Urology. 63(3), 521-527. https://doi.org/10.1016/j.eururo.2012.06.003