Journalartikel

Jahr der Veröffentlichung: 2012

Seiten: 12383-12400

Zeitschrift: International Journal of Molecular Sciences

Bandnummer: 13

Heftnummer: 10

ISSN: 1422-0067

Open Access Status: Gold

DOI Link: https://doi.org/10.3390/ijms131012383

Verlag: MDPI

Abstract: 
Protein arginine methylation is a novel posttranslational modification that plays a pivotal role in a variety of intracellular events, such as signal transduction, protein-protein interaction and transcriptional regulation, either by the direct regulation of protein function or by metabolic products originating from protein arginine methylation that influence nitric oxide (NO)-dependent processes. A growing body of evidence suggests that both mechanisms are implicated in cardiovascular and pulmonary diseases. This review will present and discuss recent research on PRMTs and the methylation of non-histone proteins and its consequences for the pathogenesis of various lung disorders, including lung cancer, pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease and asthma. This article will also highlight novel directions for possible future investigations to evaluate the functional contribution of arginine methylation in lung homeostasis and disease.

Harvard-Zitierstil: Zakrzewicz, D., Zakrzewicz, A., Preissner, K., Markart, P. and Wygrecka, M. (2012) Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders, International Journal of Molecular Sciences, 13(10), pp. 12383-12400. https://doi.org/10.3390/ijms131012383

APA-Zitierstil: Zakrzewicz, D., Zakrzewicz, A., Preissner, K., Markart, P., & Wygrecka, M. (2012). Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders. International Journal of Molecular Sciences. 13(10), 12383-12400. https://doi.org/10.3390/ijms131012383