Journal article

Publication year: 2012

Pages: 919-924

Journal: European Respiratory Journal

Volume number: 40

Issue number: 4

ISSN: 0903-1936

eISSN: 1399-3003

Open access status: Bronze

DOI Link: https://doi.org/10.1183/09031936.00176711

Publisher: European Respiratory Society

Abstract: 

Sleep-disordered breathing (SOB) may trigger thromboembolic events by enhancing intravascular clot formation. The primary objective of the present nested case-control study was to investigate whether the prevalence of SDB is increased in patients with deep vein thrombosis (DVT) and/or acute pulmonary embolism (PE).

82 consecutive patients with DVT and/or PE (cases) were prospectively enrolled irrespective of SDB-related symptoms and formed matched pairs with patients without DVT and/or PE (controls) according to sex and pre-defined categories of age and body mass index.

The prevalence of SDB (respiratory disturbance index assessed by polygraphy >= 15 events.h(-1)) was significantly greater in the cases with DVT and/or PE than in controls (40 versus 26%, p=0.046) and was predominantly obstructive in nature. Multiple regression analysis revealed that SDB was significantly associated with DVT and/or PE (OR 2.28, 95% CI 1.08-4.85; p=0.032) independent of established risk factors for thrombosis. In the sex-specific analyses this association was significant in females (OR 4.14, 95% CI 1.05-16.36; p=0.042), but not in males (OR 1.55, 95% CI 0.57-4.21; p=0.391).

SDB occurs more frequently in females with DVT and/or PE than in controls matched for anthropometric variables, and is independently associated with the occurrence of these thromboembolic events.

Harvard Citation style: Arzt, M., Luigart, R., Schum, C., Luethje, L., Stein, A., Koper, I., et al. (2012) Sleep-disordered breathing in deep vein thrombosis and acute pulmonary embolism, European Respiratory Journal, 40(4), pp. 919-924. https://doi.org/10.1183/09031936.00176711

APA Citation style: Arzt, M., Luigart, R., Schum, C., Luethje, L., Stein, A., Koper, I., Hecker, C., Dumitrascu, R., & Schulz, R. (2012). Sleep-disordered breathing in deep vein thrombosis and acute pulmonary embolism. European Respiratory Journal. 40(4), 919-924. https://doi.org/10.1183/09031936.00176711