Journal article
Authors list: Rath, Timo; Menendez, Katrin Menendez; Kuegler, Marion; Hage, Lisa; Wenzel, Christian; Schulz, Richard; Graf, Juergen; Naehrlich, Lutz; Roeb, Elke; Roderfeld, Martin
Publication year: 2012
Pages: 780-787
Journal: Digestive and Liver Disease
Volume number: 44
Issue number: 9
ISSN: 1590-8658
DOI Link: https://doi.org/10.1016/j.dld.2012.04.008
Publisher: Elsevier
Background: Cystic fibrosis (CF) associated liver disease develops in approximately 30% of CF patients. However, routine sensitive diagnostic tools are lacking. Aims: We aimed to compare the value of transient elastography and experimental fibrosis markers for the detection of liver disease in CF patients. Methods: 145 CF patients (75 children, 70 adults) were prospectively studied and received transient elastography. CF liver disease was diagnosed according to recent guidelines. Serum concentrations of YKL-40, HA, PIIIP, MMP-9, TIMP-1 and TIMP-2 were determined by ELISA. Results: Transient elastography was increased in adults and children with CF hepatopathy compared to those without and exhibited a high diagnostic accuracy for CF liver disease. In adults with portal hypertension, elastography was further enhanced. TIMP-2 was elevated in adults with CF hepatopathy associated portal hypertension and exhibited a high diagnostic accuracy for portal hypertension in adults and for CF hepatopathy in children. TIMP-1 had a high diagnostic accuracy for CF hepatopathy in adults. Diagnostic sensitivities were increased when elastography and respective biomarkers were combined for the detection of CF hepatopathy and portal hypertension. Conclusions: TIMP-1 and TIMP-2 represent powerful biomarkers for CF associated liver disease and portal hypertension. Their determination may confirm and improve the diagnostic accuracy of transient elastography. (C) 2012 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Abstract:
Citation Styles
Harvard Citation style: Rath, T., Menendez, K., Kuegler, M., Hage, L., Wenzel, C., Schulz, R., et al. (2012) TIMP-1/-2 and transient elastography allow non invasive diagnosis of cystic fibrosis associated liver disease, Digestive and Liver Disease, 44(9), pp. 780-787. https://doi.org/10.1016/j.dld.2012.04.008
APA Citation style: Rath, T., Menendez, K., Kuegler, M., Hage, L., Wenzel, C., Schulz, R., Graf, J., Naehrlich, L., Roeb, E., & Roderfeld, M. (2012). TIMP-1/-2 and transient elastography allow non invasive diagnosis of cystic fibrosis associated liver disease. Digestive and Liver Disease. 44(9), 780-787. https://doi.org/10.1016/j.dld.2012.04.008
Keywords
CHRONIC HEPATITIS-C; CIRRHOSIS; extracellular matrix; HEPATOBILIARY DISEASE; LIVER FIBROSIS; MATRIX METALLOPROTEINASES; TISSUE INHIBITOR; tissue inhibitors of metalloproteinases
