Journalartikel

Jahr der Veröffentlichung: 2012

Seiten: 203-206

Zeitschrift: Journal of Physical and Rehabilitation Medicine

Bandnummer: 22

Heftnummer: 4

ISSN: 0940-6689

eISSN: 1439-085X

DOI Link: https://doi.org/10.1055/s-0032-1316334

Verlag: Georg Thieme Verlag

Abstract: 

Introduction: Secondary osteoporosis is a frequent complication in ankylosing spondylitis (AS). Loss of bone mass in AS is the result of an imbalance of catabolic and anabolic mechanisms of bone metabolism in response to different factors.

Question/Method: The effects of serial low-dose radon and hyperthermia exposure in a therapeutic adit (12 visits to the adit in 3 weeks) on the serum levels of the cytokines osteoprotegerin (OPG), receptor activator of NF kappa-B ligand (RANKL), tumor necrosis factor-alpha (TNF-alpha), and also on the RANKL/OPG ratio as a marker of bone metabolism were investigated in 24 patients with chronic AS (mean age 58 years) and an age-matched group of 24 patients with osteoarthritis (OA). Cytokine measurements were performed at baseline and after completion of the serial treatment. Medication in both groups was limited to non-steroidal antiinflammatory drugs (NSAIDs) as needed, whereas treatment with TNF inhibitors or any drug, which could potentially influence bone metabolism, was excluded.

Results: AS-patients showed a tendency towards decrease of TNF-alpha serum levels whereas OA-patients achieved a significant decrease (p<0.0005). Both groups showed significantly decreased levels of RANKL (AS: p < 0.0005, OA: p<0.004). In contrast, only the AS-patients presented a significant increase of OPG (p<0.0005) and a significant decrease of the RANKL/OPG ratio (p<0.005).

Conclusions: In patients with chronic AS, serial low-dose radon and hyperthermia exposure in a therapeutic adit results in a reduction of osteocatabolic and an increase of osteoanabolic cytokine levels, which represents the molecular basis for inhibiting osteoclastic activity in secondary osteoporosis of inflammatory disease. Thus, serial radon(adit) therapy has an important role in a multimodaly treatment strategy for AS.

Harvard-Zitierstil: Lange, U., Neumann, N., Kuerten, B., Mueller-Ladner, U. and Tarner, I. (2012) The Impact of Serial Low-Dose Radon and Hyperthermia Exposure in a Therapeutic Adit on Pivotal Cytokines of Bone Metabolism in Ankylosing Spondylitis, Journal of Physical and Rehabilitation Medicine, 22(4), pp. 203-206. https://doi.org/10.1055/s-0032-1316334

APA-Zitierstil: Lange, U., Neumann, N., Kuerten, B., Mueller-Ladner, U., & Tarner, I. (2012). The Impact of Serial Low-Dose Radon and Hyperthermia Exposure in a Therapeutic Adit on Pivotal Cytokines of Bone Metabolism in Ankylosing Spondylitis. Journal of Physical and Rehabilitation Medicine. 22(4), 203-206. https://doi.org/10.1055/s-0032-1316334