Journal article
Authors list: Kraemer, Heidrun H.
Publication year: 2012
Pages: 4546-4549
Journal: Current Pharmaceutical Design
Volume number: 18
Issue number: 29
ISSN: 1381-6128
Publisher: Bentham Science Publishers
Abstract:
Limb trauma can lead to the development of a complex regional pain syndrome (CRPS). CRPS is a descriptive term of a variety of different symptoms. According to the current IASP-approved criteria, human CRPS can be diagnosed if a combination of signs is present: continuing pain and hyperalgesia, disproportionate to the initial trauma, skin temperature and colour asymmetry, sweating asymmetry, edema, decreased range of motion, and trophic changes. The diagnosis and treatment of human CRPS can be demanding and the pathophysiology underlying the disease is still under investigation. Immunological aspects are considered to play an important role in the development of CRPS. The impact of elevated pro-inflammatory cytokines systemically as well as locally, increased neurogenic inflammation and auto-antibodies in the pathophysiological development of CRPS are discussed in this review.
Citation Styles
Harvard Citation style: Kraemer, H. (2012) Immunological Aspects of the Complex Regional Pain Syndrome (CRPS), Current Pharmaceutical Design, 18(29), pp. 4546-4549
APA Citation style: Kraemer, H. (2012). Immunological Aspects of the Complex Regional Pain Syndrome (CRPS). Current Pharmaceutical Design. 18(29), 4546-4549.
Keywords
AUTOIMMUNITY; CRPS; FACILITATED NEUROGENIC INFLAMMATION; NERVE GROWTH-FACTOR; NEUTRAL ENDOPEPTIDASE NEP; NOCICEPTIVE ABNORMALITIES; PROINFLAMMATORY CYTOKINES; REFLEX SYMPATHETIC DYSTROPHY; SYNDROME TYPE-1; SYNDROME TYPE-I
