Journal article

Publication year: 2012

Pages: 311-317

Journal: Biomarkers in Medicine

Volume number: 6

Issue number: 3

ISSN: 1752-0363

eISSN: 1752-0371

DOI Link: https://doi.org/10.2217/BMM.12.21

Publisher: Taylor and Francis

Abstract: 
Aim: To evaluate HE4 as a potential biomarker for acute epididymitis. Materials & methods: HE4 levels in serum were measured in 62 patients with acute epididymitis and 62 age-matched male controls. Results: Both patients with epididymitis and the controls showed median HE4 values of 42 pmol/l (range: 10-560 pmol/l) and 34 pmol/l (range: 2-300 pmol/l), respectively (p = 0.3). Levels of HE4 did not change in the course of the treatment in patients with epididymitis. Regression analysis revealed no significant association between HE4 and any infection-linked variable. Multivariate analysis resulted in a number of factors associated with increased HE4 levels, which were renal dysfunction, cardiovascular diseases and malignancies. Conclusion: Although HE4 is not a biomarker for epididymitis and infection, it qualifies as a candidate for identifying patients with increased morbidity.

Harvard Citation style: Pilatz, A., Buerger, M., Luedecke, G., Wagenlehner, F. and Weidner, W. (2012) Clinical evaluation of human epididymis protein 4 as a biomarker for epididymitis, Biomarkers in Medicine, 6(3), pp. 311-317. https://doi.org/10.2217/BMM.12.21

APA Citation style: Pilatz, A., Buerger, M., Luedecke, G., Wagenlehner, F., & Weidner, W. (2012). Clinical evaluation of human epididymis protein 4 as a biomarker for epididymitis. Biomarkers in Medicine. 6(3), 311-317. https://doi.org/10.2217/BMM.12.21