Journalartikel

Jahr der Veröffentlichung: 2012

Seiten: 321-330

Zeitschrift: Research in Veterinary Science

Bandnummer: 93

Heftnummer: 1

ISSN: 0034-5288

eISSN: 1532-2661

DOI Link: https://doi.org/10.1016/j.rvsc.2011.06.010

Verlag: Elsevier

Abstract: 

The aim of this prospective study was to characterize the response of the coagulation system to a defined sterile localized inflammatory process.

Tissue cages were implanted subcutaneously in five healthy Beagles. After 9-10 weeks, local inflammation was induced by an injection of 0.5 ml 1% carrageenan. Serial samples of tissue cage fluid (TCF) and blood were collected at 10 time points (0-168 h). Nucleated cells (NC) of TCF were counted automatically to characterize local inflammation. C-reactive protein (CRP), leukocytes and coagulation variables (PT, aPTT, fibrinogen, factor VIII, antithrombin, protein C. protein S, and D-dimers) were determined in blood samples.

Carrageenan induced a significant 32-fold increase of NCs in TCF (P < 0.0001). A slight increase in leukocytes (P < 0.0001) was observed. There was a significant 1.3- to 1.5-fold increase in protein C (P = 0.0001) and protein S (P = 0.0028). CRP, secondary hemostasis and fibrinolysis did not change. The mild increase from baseline in PC/PS, may reflect a physiological counter reaction. (C) 2011 Elsevier Ltd. All rights reserved.

Harvard-Zitierstil: Bauer, N., Mensinger, S., Daube, G., Failing, K. and Moritz, A. (2012) A moderate aseptic local inflammation does not induce a significant systemic inflammatory response, Research in Veterinary Science, 93(1), pp. 321-330. https://doi.org/10.1016/j.rvsc.2011.06.010

APA-Zitierstil: Bauer, N., Mensinger, S., Daube, G., Failing, K., & Moritz, A. (2012). A moderate aseptic local inflammation does not induce a significant systemic inflammatory response. Research in Veterinary Science. 93(1), 321-330. https://doi.org/10.1016/j.rvsc.2011.06.010