Journalartikel

Jahr der Veröffentlichung: 2012

Seiten: 329-335

Zeitschrift: Journal of Controlled Release

Bandnummer: 158

Heftnummer: 2

ISSN: 0168-3659

eISSN: 1873-4995

DOI Link: https://doi.org/10.1016/j.jconrel.2011.10.030

Verlag: Elsevier

Abstract: 

Numerous studies have addressed the controlled pulmonary drug delivery properties of colloidal particles. However, only scant information on the potential of spray-drying for submicron particle preparation is available. By exploiting the advantages of spray-drying, the characteristics of submicron particles can be optimized to meet the requirements necessary for lung application.

Submicron particles were prepared from organic poly(D,L-lactide-co-glycolide) (PLGA) solutions, and composite particles were spray-dried from aqueous PLGA nanosuspensions. The feed concentration, as well as the spray-mesh diameter influenced the resulting particle sizes. Nanoparticles were virtually unaffected after spray-drying. The aerodynamic characteristics of both particle species revealed aerosol particle sizes suitable for deposition in the deep lungs (<= 4 mu m). While the entrapped drug was released within similar to 90 min from the composite particles, extensive drug retardation (similar to 480 min) was observed for PLGA particles spray-dried from organic solution.

These results suggest that nanospray-drying is a convenient method to prepare submicron, controlled drug delivery vehicles useful for pulmonary application potentially allowing access to alveolar tissue. (C) 2011 Elsevier B.V. All rights reserved.

Harvard-Zitierstil: Beck-Broichsitter, M., Schweiger, C., Schmehl, T., Gessler, T., Seeger, W. and Kissel, T. (2012) Characterization of novel spray-dried polymeric particles for controlled pulmonary drug delivery, Journal of Controlled Release, 158(2), pp. 329-335. https://doi.org/10.1016/j.jconrel.2011.10.030

APA-Zitierstil: Beck-Broichsitter, M., Schweiger, C., Schmehl, T., Gessler, T., Seeger, W., & Kissel, T. (2012). Characterization of novel spray-dried polymeric particles for controlled pulmonary drug delivery. Journal of Controlled Release. 158(2), 329-335. https://doi.org/10.1016/j.jconrel.2011.10.030