Journal article

Publication year: 2012

Pages: 308-313

Journal: Respiratory Medicine

Volume number: 106

Issue number: 2

ISSN: 0954-6111

eISSN: 1532-3064

Open access status: Bronze

DOI Link: https://doi.org/10.1016/j.rmed.2011.10.018

Publisher: Elsevier

Abstract: 

Background: Patients with pulmonary arterial hypertension often present with a mild obstructive lung pattern, however, the functional consequences are not known.

Methods: We analysed flow volume loops during exercise in 61 patients with precapillary pulmonary hypertension (PH) (age 55 +/- 14 years) in comparison with 21 patients with COPD (60 +/- 12 years), 39 patients with pulmonary fibrosis (58 +/- 11 years) and 38 healthy controls (HC) (39 +/- 15 years). Inspiratory capacity (IC) was measured at rest, and during maximum exercise (max).

Results: HC exhibited a stable IC of 3.0 +/- 0.91 at rest, and at max. A reduction in IC of 2.6 +/- 0.8 l at rest to 2.0 +/- 0.7 l at max was observed in patients with COPD. Patients with PH exhibited a significant reduction in IC from 2.3 +/- 0.6 l at rest to 2.1 +/- 0.6 l at max, while patients with pulmonary fibrosis exhibited a stable IC of 1.8 +/- 0.6 at rest and 1.7 +/- 0.6 l at max. In patients with PH, a weak negative correlation was drawn between the change in IC (%) and peak VO2 (r = -0.29, p = 0.01), as well as with PVR (r = -0.27, p = 0.02).

Conclusion: Patients with PH demonstrate a characteristic change in IC during exercise, which might contribute to impaired exercise tolerance. C) 2011 Elsevier Ltd. All rights reserved.

Harvard Citation style: Richter, M., Voswinckel, R., Tiede, H., Schulz, R., Tanislav, C., Feustel, A., et al. (2012) Dynamic hyperinflation during exercise in patients with precapillary pulmonary hypertension, Respiratory Medicine, 106(2), pp. 308-313. https://doi.org/10.1016/j.rmed.2011.10.018

APA Citation style: Richter, M., Voswinckel, R., Tiede, H., Schulz, R., Tanislav, C., Feustel, A., Morty, R., Ghofrani, H., Seeger, W., & Reichenberger, F. (2012). Dynamic hyperinflation during exercise in patients with precapillary pulmonary hypertension. Respiratory Medicine. 106(2), 308-313. https://doi.org/10.1016/j.rmed.2011.10.018