Journal article

Publication year: 2011

Pages: 2330-2334

Journal: Journal of International Medical Research

Volume number: 39

Issue number: 6

ISSN: 0300-0605

Open access status: Hybrid

DOI Link: https://doi.org/10.1177/147323001103900632

Publisher: SAGE Publications

Abstract: 
Microsomal cytochrome P450 is an important enzyme involved in drug metabolism and bioactivation in the liver. In guinea-pigs, the specific amount of cytochrome P450 depends on dietary vitamin C intake. Short-term vitamin C treatment can induce non-genomic effects on hepatocytes, such as activating mitochondrial respiration without changing cytochrome concentration. The aim of this investigation was to elucidate the long-term effects of a low or high vitamin C diet on the quantity and size of mitochondria in the hepatocytes of guinea-pigs. After 6 - 8 weeks of vitamin C feeding, the group receiving a low vitamin C content in their food (10 mg/100 g food) had significantly less mitochondria, but of a larger size, than the group receiving a high vitamin C content (680 mg/100 g food). This animal model investigation demonstrated that long-term treatment with vitamin C can induce morphological changes in the mitochondria of hepatocytes.

Harvard Citation style: Feuring, M., Schultz, A. and Hersemeyer, K. (2011) Long-term, High Intake of Vitamin C Decreases Size and Increases Quantity of Liver Mitochondria in Guinea-pigs, Journal of International Medical Research, 39(6), pp. 2330-2334. https://doi.org/10.1177/147323001103900632

APA Citation style: Feuring, M., Schultz, A., & Hersemeyer, K. (2011). Long-term, High Intake of Vitamin C Decreases Size and Increases Quantity of Liver Mitochondria in Guinea-pigs. Journal of International Medical Research. 39(6), 2330-2334. https://doi.org/10.1177/147323001103900632