Journal article

Publication year: 2011

Pages: 1131-1139

Journal: Journal of Periodontology

Volume number: 82

Issue number: 8

ISSN: 0022-3492

eISSN: 1943-3670

DOI Link: https://doi.org/10.1902/jop.2011.100287

Publisher: Wiley

Abstract: 

Background: We aimed to analyze clinical, microbiologic, and serologic effects of chlorhexidine (CHX) chips used as a subgingival controlled-release delivery device before and immediately after scaling and root planing (SRP).

Methods: Twenty-four patients presenting with >= 12 teeth with probing depth (PD) >= 5 mm and bleeding on probing were assigned in test or control groups. After prophylaxis, CHX chips (test) or placebo chips (control) were placed in pockets with PD >= 5 mm. Ten days later, SRP was performed in all teeth with PD >= 4 mm in a single appointment. Immediately after SRP, new chips were inserted in all pockets with PD >= 5 mm. Parameters were assessed at baseline; beginning of SRP; and 1, 3, and 6 months after treatment. Subgingival samples were obtained at baseline; beginning of SRP; and at 1 month after treatment. Periodontal pathogens Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, and Treponema denticola were analyzed. Serum levels of high sensitive C-reactive and lipopolysaccharide-binding proteins were measured. The changes of the parameters between and within the groups were tested by Mann-Whitney U test (P<0.05).

Results: All clinical and serologic parameters improved in both groups over time. There was a significant difference in clinical attachment level (CAL) gain from baseline to 6 months between groups (1.17 mm in the test group versus 0.79 mm in the placebo group) (P <0.05). The treatment with CHX chips showed a greater reduction of the microorganisms of the "red complex" after 1 month (P = 0.02).

Conclusion: The use of CHX chips before and immediately after SRP improved CAL and reduced the subgingival microorganisms of the red complex in the treatment of chronic periodontitis. J Periodontol 2011;82 :1131-1139.

Harvard Citation style: Gonzales, J., Harnack, L., Schmitt-Corsitto, G., Boedeker, R., Chakraborty, T., Domann, E., et al. (2011) A Novel Approach to the Use of Subgingival Controlled-Release Chlorhexidine Delivery in Chronic Periodontitis: A Randomized Clinical Trial, Journal of Periodontology, 82(8), pp. 1131-1139. https://doi.org/10.1902/jop.2011.100287

APA Citation style: Gonzales, J., Harnack, L., Schmitt-Corsitto, G., Boedeker, R., Chakraborty, T., Domann, E., & Meyle, J. (2011). A Novel Approach to the Use of Subgingival Controlled-Release Chlorhexidine Delivery in Chronic Periodontitis: A Randomized Clinical Trial. Journal of Periodontology. 82(8), 1131-1139. https://doi.org/10.1902/jop.2011.100287