Journalartikel
Autorenliste: Hermes, Sandra; Hennig, Juergen; Stingl, Markus; Leichsenring, Falk; Leweke, Frank
Jahr der Veröffentlichung: 2011
Seiten: 51-61
Zeitschrift: Zeitschrift für psychosomatische Medizin und Psychotherapie : Organ der Deutschen Gesellschaft für Psychosomatische Medizin und Ärztliche Psychotherapie (DGPM)
Bandnummer: 57
Heftnummer: 1
ISSN: 1438-3608
eISSN: 2196-8349
DOI Link: https://doi.org/10.13109/zptm.2011.57.1.51
Verlag: Vandenhoeck & Ruprecht
Objectives: Reduced concentrations of dopamine in prefrontal brain structures may play a role in alexithymia. Dopamine degradation in the orbitofrontal cortex is regulated by catechol-O-methyltransferase (COMT), and a functional single nucleotide polymorphism of the COMT gene, Val158Met, has been related to psychiatric illness. This study examines the association between the COMT Val158Met gene polymorphism, and alexithymia. Methods: 120 healthy students and 120 patients with mental disorders were genotyped for the COMT Val158Met polymorphism. Additionally, the Toronto Alexithymia Scale (TAS-20) was administered. Results: COMT genotype did not show a significant correlation with the TAS-20 in either group. Conclusions: COMT Val158Met polymorphism alone does not seem to be a major factor in alexithymia in healthy students. This is true even if patients with mental disorders covering a broader range of alexithymia are included. Thus, other genes, possibly interacting with cultural, environmental, and developmental factors, may be implicated.
Abstract:
Zitierstile
Harvard-Zitierstil: Hermes, S., Hennig, J., Stingl, M., Leichsenring, F. and Leweke, F. (2011) No association between catechol-O-methyltransferase val158met polymorphism and alexithymia, Zeitschrift für psychosomatische Medizin und Psychotherapie : Organ der Deutschen Gesellschaft für Psychosomatische Medizin und Ärztliche Psychotherapie (DGPM), 57(1), pp. 51-61. https://doi.org/10.13109/zptm.2011.57.1.51
APA-Zitierstil: Hermes, S., Hennig, J., Stingl, M., Leichsenring, F., & Leweke, F. (2011). No association between catechol-O-methyltransferase val158met polymorphism and alexithymia. Zeitschrift für psychosomatische Medizin und Psychotherapie : Organ der Deutschen Gesellschaft für Psychosomatische Medizin und Ärztliche Psychotherapie (DGPM). 57(1), 51-61. https://doi.org/10.13109/zptm.2011.57.1.51
Schlagwörter
ALEXITHYMIA; FUNCTIONAL POLYMORPHISM; Healthy Students; Psychosomatic Patients; TRAIT; TWIN; Val158met-Polymorphism
