Journal article

Publication year: 2010

Pages: 282-291

Journal: Respiratory Physiology & Neurobiology

Volume number: 174

Issue number: 3

ISSN: 1569-9048

eISSN: 1878-1519

DOI Link: https://doi.org/10.1016/j.resp.2010.08.013

Publisher: Elsevier

Abstract: 
Hypoxic pulmonary vasoconstriction (HPV) is an essential physiological mechanism of the lung that matches blood perfusion with alveolar ventilation to optimize gas exchange. Perturbations of HPV, as may occur in pneumonia or adult respiratory distress syndrome, can cause life-threatening hypoxemia. Despite intensive research for decades, the molecular mechanisms of HPV have not been fully elucidated. Reactive oxygen species (ROS) and changes in the cellular redox state are proposed to link O-2 sensing and pulmonary arterial smooth muscle cell contraction underlying HPV. In this regard, mitochondria and NAD(P)H oxidases are discussed as sources of ROS. However, there is controversy whether ROS levels decrease or increase during hypoxia. With this background we summarize the current knowledge on the role of ROS and redox state in HPV. (C) 2010 Elsevier B.V. All rights reserved.

Harvard Citation style: Fuchs, B., Sommer, N., Dietrich, A., Schermuly, R., Ghofrani, H., Grimminger, F., et al. (2010) Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction, Respiratory Physiology & Neurobiology, 174(3), pp. 282-291. https://doi.org/10.1016/j.resp.2010.08.013

APA Citation style: Fuchs, B., Sommer, N., Dietrich, A., Schermuly, R., Ghofrani, H., Grimminger, F., Seeger, W., Gudermann, T., & Weissmann, N. (2010). Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction. Respiratory Physiology & Neurobiology. 174(3), 282-291. https://doi.org/10.1016/j.resp.2010.08.013