Journal article
Authors list: Beck-Broichsitter, Moritz; Thieme, Marcel; Nguyen, Juliane; Schmehl, Thomas; Gessler, Tobias; Seeger, Werner; Agarwal, Seema; Greiner, Andreas; Kissel, Thomas
Publication year: 2010
Pages: 1527-1535
Journal: Macromolecular Bioscience
Volume number: 10
Issue number: 12
ISSN: 1616-5187
eISSN: 1616-5195
DOI Link: https://doi.org/10.1002/mabi.201000100
Publisher: Wiley
Abstract:
Novel 'nano in nano' composites consisting of biodegradable polymer nanoparticles incorporated into polymer nanofibers may efficiently modulate drug delivery. This is shown here using a combination of model compound-loaded biodegradable nanoparticles encapsulated in electrospun fibers. The dye coumarin 6 is used as model compound for a drug in order to simulate drug release from loaded poly(lactide-co-glycolide) nanoparticles. Dye release from the nanoparticles occurs immediately in aqueous solution. Dye-loaded nanoparticles which are encapsulated by electrospun polymer nanofibers display a significantly retarded release.
Citation Styles
Harvard Citation style: Beck-Broichsitter, M., Thieme, M., Nguyen, J., Schmehl, T., Gessler, T., Seeger, W., et al. (2010) Novel 'Nano in Nano' Composites for Sustained Drug Delivery: Biodegradable Nanoparticles Encapsulated into Nanofiber Non-Wovens, Macromolecular Bioscience, 10(12), pp. 1527-1535. https://doi.org/10.1002/mabi.201000100
APA Citation style: Beck-Broichsitter, M., Thieme, M., Nguyen, J., Schmehl, T., Gessler, T., Seeger, W., Agarwal, S., Greiner, A., & Kissel, T. (2010). Novel 'Nano in Nano' Composites for Sustained Drug Delivery: Biodegradable Nanoparticles Encapsulated into Nanofiber Non-Wovens. Macromolecular Bioscience. 10(12), 1527-1535. https://doi.org/10.1002/mabi.201000100
Keywords
biodegradable; composite materials; controlled drug delivery; CONTROLLED-RELEASE; ELECTROSPUN; FIBERS; HYDROCHLORIDE; MATS; nanofiber non-wovens; PLA; PLGA
