Journal article

Publication year: 2010

Pages: 458-468

Journal: Trends in Molecular Medicine

Volume number: 16

Issue number: 10

ISSN: 1471-4914

eISSN: 1471-499X

DOI Link: https://doi.org/10.1016/j.molmed.2010.07.004

Publisher: Cell Press

Abstract: 
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial hyperplasia and progressive joint destruction. Rheumatoid arthritis synovial fibroblasts (RASFs) are leading cells in joint erosion and contribute actively to inflammation. RASFs show an activated phenotype that is independent of the inflammatory environment and requires the combination of several factors. Although new aspects regarding RASF activation via matrix degradation products, epigenetic modifications, inflammatory factors, Toll-like receptor (TLR) activation and others have recently been uncovered, the primary pathophysiological processes in early arthritis leading to permanent activation are mostly unknown. Here, we review new findings regarding RASF activation and their altered behavior that contribute to matrix destruction and inflammation as well as their potential to spread RA.

Harvard Citation style: Neumann, E., Lefevre, S., Zimmermann, B., Gay, S. and Mueller-Ladner, U. (2010) Rheumatoid arthritis progression mediated by activated synovial fibroblasts, Trends in Molecular Medicine, 16(10), pp. 458-468. https://doi.org/10.1016/j.molmed.2010.07.004

APA Citation style: Neumann, E., Lefevre, S., Zimmermann, B., Gay, S., & Mueller-Ladner, U. (2010). Rheumatoid arthritis progression mediated by activated synovial fibroblasts. Trends in Molecular Medicine. 16(10), 458-468. https://doi.org/10.1016/j.molmed.2010.07.004