Journal article

Publication year: 2010

Pages: 376-384

Journal: European Journal of Oral Sciences

Volume number: 118

Issue number: 4

ISSN: 0909-8836

eISSN: 1600-0722

DOI Link: https://doi.org/10.1111/j.1600-0722.2010.00742.x

Publisher: Wiley

Abstract: 
Solutions containing tin and fluoride exhibit remarkable anti-erosive properties with tin ions as a major agent. To elucidate its mechanism of action in dentine, the tin uptake on and in the tissue was investigated and related to histological findings and substance loss. Samples were treated twice daily, each treatment lasting for 2 min, with fluoride solutions [pH 4.5; 1,500 parts per million (p.p.m.) F] containing 2,100, 1,400, or 400 p.p.m. Sn as SnCl2. In experiments 1 and 2, samples were eroded with citric acid (pH 2.3) six times each day, each treatment lasting for 5 min; in experiment 2, the demineralized organic matrix was continuously digested by collagenase; in experiment 3, no erosive challenges were performed. Sample surfaces and cross-sections were investigated using energy dispersive X-ray spectroscopy, scanning electron microscopy, and profilometry. Surface retention of tin was found in almost all treatment groups and was highest in experiment 2. On cross-sections, tin was retained within the organic matrix; in mineralized areas, tin was found mainly within a depth of 10 mu m. Test solutions inhibited substance loss significantly; in experiment 2, the effect was dose-dependent. Erosion inhibition seemed to depend mainly on the incorporation of tin in the mineralized dentine when the organic portion was preserved, but on surface precipitation when the organic portion was continuously digested.

Harvard Citation style: Ganss, C., Hardt, M., Lussi, A., Cocks, A., Klimek, J. and Schlueter, N. (2010) Mechanism of action of tin-containing fluoride solutions as anti-erosive agents in dentine - an in vitro tin-uptake, tissue loss, and scanning electron microscopy study, European Journal of Oral Sciences, 118(4), pp. 376-384. https://doi.org/10.1111/j.1600-0722.2010.00742.x

APA Citation style: Ganss, C., Hardt, M., Lussi, A., Cocks, A., Klimek, J., & Schlueter, N. (2010). Mechanism of action of tin-containing fluoride solutions as anti-erosive agents in dentine - an in vitro tin-uptake, tissue loss, and scanning electron microscopy study. European Journal of Oral Sciences. 118(4), 376-384. https://doi.org/10.1111/j.1600-0722.2010.00742.x