Conference paper

Publication year: 2010

Pages: 817-827

Journal: Theriogenology

Volume number: 73

Issue number: 6

ISSN: 0093-691X

eISSN: 1879-3231

DOI Link: https://doi.org/10.1016/j.theriogenology.2009.11.003

Conference: EU COST Workshop on Experimental Models in Animal Reproduction

Publisher: Elsevier

Abstract: 
Both exogenous and endogenous factors during pregnancy may impact placental vascular development and cause different malformations of placental vessels. In humans, consequences of abnormal vascular development have been associated with different pregnancy-related pathologies ranging from miscarriage to intrauterine growth restriction or preeclampsia. Pregnancy-associated exposure to bacterial or viral infections or pharmacologic or toxic agents may also influence vascular development of the placenta and lead to preterm labor and delivery. Several steps of vascular adaptation on both the fetal and maternal side are necessary and include such events as uterine vasodilation, remodeling by extravillous trophoblast, as well as vasculogenesis and angiogenesis within the placenta. Ubiquitous as well as pregnancy-specific angiogenic factors are involved. Morphologic and stereologic approaches, as well as experiments in established laboratory animals, cannot be applied to large domestic animals or humans without hesitation. Thus, further studies into the different aspects of this process will require an appropriate in vitro model of placental vascular development. Reflecting the core of placental vascular development, the in vitro model should facilitate the interactions between trophoblast and stromal cells with endothelial progenitor cells. The effects of viral or bacterial infection as well as pharmacologic or toxic agents may be studied more closely in the process. This report reviews major aspects of vascular development in the placenta and describes the establishment of a three-dimensional in vitro model of human placental vascular development. (C) 2010 Published by Elsevier Inc.

Harvard Citation style: Herr, F., Baal, N., Widmer-Teske, R., McKinnon, T. and Zygmunt, M. (2010) How to study placental vascular development?, Theriogenology, 73(6), pp. 817-827. https://doi.org/10.1016/j.theriogenology.2009.11.003

APA Citation style: Herr, F., Baal, N., Widmer-Teske, R., McKinnon, T., & Zygmunt, M. (2010). How to study placental vascular development?. Theriogenology. 73(6), 817-827. https://doi.org/10.1016/j.theriogenology.2009.11.003