Journal article

Publication year: 2010

Pages: 160-172

Journal: Cancer Cell

Volume number: 17

Issue number: 2

ISSN: 1535-6108

eISSN: 1878-3686

Open access status: Bronze

DOI Link: https://doi.org/10.1016/j.ccr.2009.12.044

Publisher: Cell Press

Abstract: 
Matrix metalloproteinase-9 (MMP-9) is the major MMP produced by B-CLL cells and contributes to their tissue infiltration by degrading extracellular and membrane-anchored substrates. Here we describe a different function for MMP-9 in B-CLL, which involves the hemopexin domain rather than its catalytic function. Binding of soluble or immobilized (pro)MMP-9, a catalytically inactive proMMP-9 mutant, or the MMP-9 hemopexin domain to its docking receptors alpha 4 beta 1 integrin and CD44v, induces an intracellular signaling pathway that prevents B-CLL apoptosis. This pathway is induced in all B-CLL cases, is active in B-CLL lymphoid tissues, and consists of Lyn activation, STAT3 phosphorylation, and Mcl-1 upregulation. Our results establish that MMP/receptor binding induces intracellular survival signals and highlight the role of (pro)MMP-9 in B-CLL pathogenesis.

Harvard Citation style: Redondo-Munoz, J., Ugarte-Berzal, E., Jose Terol, M., Van den Steen, P., Hernandez del Cerro, M., Roderfeld, M., et al. (2010) Matrix Metalloproteinase-9 Promotes Chronic Lymphocytic Leukemia B Cell Survival through Its Hemopexin Domain, Cancer Cell, 17(2), pp. 160-172. https://doi.org/10.1016/j.ccr.2009.12.044

APA Citation style: Redondo-Munoz, J., Ugarte-Berzal, E., Jose Terol, M., Van den Steen, P., Hernandez del Cerro, M., Roderfeld, M., Roeb, E., Opdenakker, G., Garcia-Marco, J., & Garcia-Pardo, A. (2010). Matrix Metalloproteinase-9 Promotes Chronic Lymphocytic Leukemia B Cell Survival through Its Hemopexin Domain. Cancer Cell. 17(2), 160-172. https://doi.org/10.1016/j.ccr.2009.12.044