Journal article

Publication year: 2010

Pages: 1345-1358

Journal: Journal of Biomaterials Science, Polymer Edition

Volume number: 21

Issue number: 10

ISSN: 0920-5063

eISSN: 1568-5624

DOI Link: https://doi.org/10.1163/092050609X12517190417759

Publisher: Taylor and Francis Group

Abstract: 
The purpose of this study is to assess the mechanical efficacy of an alkylene bis(dilactoyl)-methacrylate-based degradable bone adhesive in 36 sheep. Bone segmentation with osteotomies of the metaphyseal ulna was performed and adhesive was applied into the osteotomy gaps in 18 sheep. The remaining 18 animals served as controls. The segment was subsequently stabilized without any osteosynthesis in all sheep. Six animals of the adhesive group and 6 controls were killed after 21, 42 and 84 days, respectively. Bond strength of the adhesive and quality of fracture healing was studied using biomechanical, histological and radiological methods. There were no significant differences in biomechanical analysis between both groups at any time. However, an increase of in vivo bond strength with the highest stiffness of 102.83 N/mm(2) was observed in the adhesive group after 84 days. In vitro analysis showed non-significant differences in bond strength during polymerization time. Histomorphometric investigations revealed significant differences in osteotomy cross-section area after 84 days, with higher areas of callus in the control. After 84 days the X-ray examinations showed completely bridged gaps in four of six animals in the adhesive and in five animals in the control group. This bone adhesive exhibited good in vivo and in vitro bond strength and mechanical efficiency in both the short and long term without impairment of physiological fracture healing. (C) Koninklijke Brill NV, Leiden, 2010

Harvard Citation style: Heiss, C., Schettler, N., Wenisch, S., Cords, S., Schilke, F., Lips, K., et al. (2010) Bond Strength of an Alkylene Bis(dilactoyl)-Methacrylate Bone Adhesive: a Biomechanical Evaluation in Sheep, Journal of Biomaterials Science, Polymer Edition, 21(10), pp. 1345-1358. https://doi.org/10.1163/092050609X12517190417759

APA Citation style: Heiss, C., Schettler, N., Wenisch, S., Cords, S., Schilke, F., Lips, K., Alt, V., & Schnettler, R. (2010). Bond Strength of an Alkylene Bis(dilactoyl)-Methacrylate Bone Adhesive: a Biomechanical Evaluation in Sheep. Journal of Biomaterials Science, Polymer Edition. 21(10), 1345-1358. https://doi.org/10.1163/092050609X12517190417759