Journal article

Publication year: 2010

Pages: 72-75

Journal: Hormone Research in Paediatrics

Volume number: 74

Issue number: 1

ISSN: 1663-2818

eISSN: 1663-2826

DOI Link: https://doi.org/10.1159/000281404

Publisher: Karger Publishers

Abstract: 
We report herein the case of a premature infant who presented with failure to thrive, hyponatremia, hyperkalemia and metabolic acidosis. Initial serum hormone profiling suggested isolated hypoaldosteronism (aldosterone: 0.01 pg/ml, normal range: 50-900 pg/ml). A gas chromatography-mass spectrometry spot urinary steroid profile showed grossly elevated levels of 18-hydroxy-tetrahydro-11-dehydrocorticosterone (18-hydroxy-THA: 5,893 mu g/l; normal upper limit 36 mu g/l) and tetrahydroaldosterone (TH-Aldo: 5,749 mu g/l; normal upper limit 36 mu g/l) which are aldosterone precursor metabolite and aldosterone metabolite, respectively. Thus, aldosterone synthase deficiency was excluded and pseudohypoaldosteronism (PHA) was suggested. A repeated test after dilution of the serum revealed a very high level of aldosterone (6,490 pg/ml), confirming the diagnosis of PHA in this case. Copyright (C) 2010 S. Karger AG, Basel

Harvard Citation style: Akin, L., Kurtoglu, S., Kendirci, M., Akin, M., Hartmann, M. and Wudy, S. (2010) Hook Effect: A Pitfall Leading to Misdiagnosis of Hypoaldosteronism in an Infant with Pseudohypoaldosteronism, Hormone Research in Paediatrics, 74(1), pp. 72-75. https://doi.org/10.1159/000281404

APA Citation style: Akin, L., Kurtoglu, S., Kendirci, M., Akin, M., Hartmann, M., & Wudy, S. (2010). Hook Effect: A Pitfall Leading to Misdiagnosis of Hypoaldosteronism in an Infant with Pseudohypoaldosteronism. Hormone Research in Paediatrics. 74(1), 72-75. https://doi.org/10.1159/000281404