Journal article

Publication year: 2010

Pages: 127-133

Journal: Cellular Immunology

Volume number: 262

Issue number: 2

ISSN: 0008-8749

eISSN: 1090-2163

DOI Link: https://doi.org/10.1016/j.cellimm.2010.02.004

Publisher: Elsevier

Abstract: 
Carriage of the TNF -308 A allele (r51800629 A) has been associated with increased serum TNF-alpha levels, the development of sepsis syndrome, and fatal outcome, in severely traumatized patients (Menges et al., 2008 [1]). Herein, we analysed the putative allelic imbalance of TNF-alpha release from myeloid cells. Circulating peripheral blood cells from healthy human blood donors (n = 104) and monocyte-derived macrophages (n = 158) were analysed for their ex vivo capacity of TNF-alpha expression. Our findings indicate that carriage of the TNF -308 A allele is not associated with high TNF-alpha expression in circulating human leucocytes and monocyte-derived macrophages. Other cellular sources, e.g. tissue-resident cells like mast cells and/or tissue specific macrophages might be the cellular source of high TNF-alpha serum levels shortly after trauma. (C) 2010 Elsevier Inc. All rights reserved.

Harvard Citation style: Wienzek, S., Kissel, K., Breithaupt, K., Lang, C., Nockher, A., Hackstein, H., et al. (2010) Tumor necrosis factor alpha gene variants do not display allelic imbalance in circulating myeloid cells, Cellular Immunology, 262(2), pp. 127-133. https://doi.org/10.1016/j.cellimm.2010.02.004

APA Citation style: Wienzek, S., Kissel, K., Breithaupt, K., Lang, C., Nockher, A., Hackstein, H., & Bein, G. (2010). Tumor necrosis factor alpha gene variants do not display allelic imbalance in circulating myeloid cells. Cellular Immunology. 262(2), 127-133. https://doi.org/10.1016/j.cellimm.2010.02.004