Journalartikel

Jahr der Veröffentlichung: 2009

Seiten: 1220-1221

Zeitschrift: Autophagy

Bandnummer: 5

Heftnummer: 8

ISSN: 1554-8627

eISSN: 1554-8635

Open Access Status: Bronze

DOI Link: https://doi.org/10.4161/auto.5.8.10177

Verlag: Taylor and Francis Group

Abstract: 
Autophagy is a pivotal bulk degradation system that eliminates undesirable molecules, damaged organelles, and misfolded protein aggregates in response to diverse stimuli, including infection. Autophagy acts to limit intracellular microbial growth but intracellular pathogens have evolved strategies to subvert host autophagic responses for their survival. We found that Listeria monocytogenes ActA, a surface protein required for actin polymerization and actin-based bacterial motility, plays a pivotal role in evading autophagy, but in a manner independent of bacterial motility. We show that L. monocytogenes exploits the biomimetic property of ActA to camouflage itself with host proteins comprised of Ena/VASP and the Arp2/3 complex, thereby escaping recognition by autophagy (Fig. 1).

Harvard-Zitierstil: Yoshikawa, Y., Ogawa, M., Hain, T., Chakraborty, T. and Sasakawa, C. (2009) Listeria monocytogenes ActA is a key player in evading autophagic recognition, Autophagy, 5(8), pp. 1220-1221. https://doi.org/10.4161/auto.5.8.10177

APA-Zitierstil: Yoshikawa, Y., Ogawa, M., Hain, T., Chakraborty, T., & Sasakawa, C. (2009). Listeria monocytogenes ActA is a key player in evading autophagic recognition. Autophagy. 5(8), 1220-1221. https://doi.org/10.4161/auto.5.8.10177