Journal article

Publication year: 2009

Pages: 577-581

Journal: Zeitschrift für Orthopädie und Unfallchirurgie

Volume number: 147

Issue number: 5

ISSN: 1864-6697

eISSN: 1864-6743

DOI Link: https://doi.org/10.1055/s-0029-1185711

Publisher: Georg Thieme Verlag

Abstract: 

Aim: Secondary osteoporosis with subsequent fractures are well-known symptoms in ankylosing spondylitis. As a possible genetic component of osteoporosis, an association between bone mineral density (BMD) and polymorphisms of the vitamin D receptor (VDR) gene has been reported.

Method: In the present study, we investigated relationships between these polymorphisms, BMD, biochemical markers of bone metabolism and markers of disease activity in ankylosing spondylitis.

Results: AS patients showed osteoporosis more frequently than healthy controls. A mapping of activity indices and BMD showed an association of lumbar and peripheral BMD as well as of the current and median C-reactive protein over the last 3 years with the used Fokl-genotypes of the VDR in male patients with AS. Female AS patients showed no significant association.

Conclusion: The pathophysiological mechanisms of this association are unclear, especially with respect to the inflammatory activity. An early assessment of the risk for osteopenia/osteoporosis in AS patients using molecular biological tests could make possible timely preventive measures or therapy.

Harvard Citation style: Lange, U., Teichmann, J. and Obermayer-Pietsch, B. (2009) Genetic Aspects of Osteopenia/Osteoporosis in Ankylosing Spondylitis, Zeitschrift für Orthopädie und Unfallchirurgie, 147(5), pp. 577-581. https://doi.org/10.1055/s-0029-1185711

APA Citation style: Lange, U., Teichmann, J., & Obermayer-Pietsch, B. (2009). Genetic Aspects of Osteopenia/Osteoporosis in Ankylosing Spondylitis. Zeitschrift für Orthopädie und Unfallchirurgie. 147(5), 577-581. https://doi.org/10.1055/s-0029-1185711