Journal article

Publication year: 2009

Pages: 549-U11

Journal: Deutsches Ärzteblatt International

Volume number: 106

Issue number: 34-35

ISSN: 1866-0452

Open access status: Green

DOI Link: https://doi.org/10.3238/arztebl.2009.0549

Publisher: Deutscher Ärzte-Verlag

Abstract: 

Background: Because of the changing dietary habits of an aging population, hyperuricemia is frequently found in combination with other metabolic disorders. Longstanding elevation of the serum uric acid level can lead to the deposition of monosodium urate crystals, causing gout (arthritis, urate nephropathy, tophi). In Germany, the prevalence of gouty arthritis is estimated at 1.4%, higher than that of rheumatoid arthritis. There are no German guidelines to date for the treatment of gout. Its current treatment is based largely on expert opinion.

Methods: Selective literature review on the diagnosis and treatment of gout.

Results and conclusions: Asymptomatic hyperuricemia is generally not an indication for pharmacological intervention to lower the uric acid level. When gout is clinically manifest, however, acute treatment of gouty arthritis should be followed by determination of the cause of hyperuricemia, and long-term treatment to lower the uric acid level is usually necessary. The goal of treatment is to diminish the body's stores of uric acid crystal deposits (the intrinsic uric acid pool) and thereby to prevent the inflammatory processes that they cause, which lead to structural alterations. In the long term, serum uric acid levels should be kept below 360 mu mol/L (6 mg/dL). The available medications for this purpose are allopurinol and various uricosuric agents, e. g., benzbromarone. There is good evidence to support the treatment of gouty attacks by the timely, short-term use of non-steroidal anti-inflammatory drugs (NSAID), colchicine, and glucocorticosteroids.

Harvard Citation style: Tausche, A., Jansen, T., Schroeder, H., Bornstein, S., Aringer, M. and Mueller-Ladner, U. (2009) Gout-Current Diagnosis and Treatment, Deutsches Ärzteblatt International, 106(34-35), pp. 549-U11. https://doi.org/10.3238/arztebl.2009.0549

APA Citation style: Tausche, A., Jansen, T., Schroeder, H., Bornstein, S., Aringer, M., & Mueller-Ladner, U. (2009). Gout-Current Diagnosis and Treatment. Deutsches Ärzteblatt International. 106(34-35), 549-U11. https://doi.org/10.3238/arztebl.2009.0549