Journal article
Authors list: Preising, M. N.; Lorenz, B.
Publication year: 2009
Pages: 311-319
Journal: Ophthalmologe
Volume number: 106
Issue number: 4
ISSN: 0941-293X
DOI Link: https://doi.org/10.1007/s00347-008-1871-3
Publisher: Springer
Abstract:
The retinal pigment epithelium (RPE) is a cellular monolayer between the choriocapillaris and the photoreceptors which controls the uptake of nutrients by the retina and the disposal of shed photoreceptor outer segments from the retina. The RPE is responsible for a continuous supply of rhodopsin by the retinol cycle and blocking of light by its pigmentation to minimize light-induced oxidation of retinal lipids and proteins. Proteins encoded by genes in which mutations are responsible for hereditary disorders of the retina and the RPE are involved in all these functions. In this article these genes and disorders are reviewed in the context of a functional network.
Citation Styles
Harvard Citation style: Preising, M. and Lorenz, B. (2009) Genetic diseases of the retinal pigment epithelium, Ophthalmologe, 106(4), pp. 311-319. https://doi.org/10.1007/s00347-008-1871-3
APA Citation style: Preising, M., & Lorenz, B. (2009). Genetic diseases of the retinal pigment epithelium. Ophthalmologe. 106(4), 311-319. https://doi.org/10.1007/s00347-008-1871-3
Keywords
ALBINISM; CELL-ADHESION; CHOROIDEREMIA; CONE DYSTROPHY; Early-onset severe retinal dystrophy; HUMAN EYES; phagocytosis; PHOTORECEPTOR OUTER SEGMENTS; retinal pigment epithelium; Retinol cycle; RPE65 GENE; VISUAL FUNCTION
