Journalartikel

Enhanced distribution of fourth-generation fluoroquinolones in prostatic tissue


AutorenlistePerletti, G.; Wagenlehner, F. M. E.; Naber, K. G.; Magrid, V.

Jahr der Veröffentlichung2009

Seiten206-210

ZeitschriftInternational Journal of Antimicrobial Agents

Bandnummer33

Heftnummer3

ISSN0924-8579

DOI Linkhttps://doi.org/10.1016/j.ijantimicag.2008.09.009

VerlagElsevier


Abstract
A recently published pharmacokinetic trial showed that the fluoroquinolone moxifloxacin administered to healthy volunteers at the single oral dose of 400 mg accumulates in prostatic secretions (PS) up to a median concentration of 3.99 mg/L and reaches a PS/plasma concentration ratio of 1.57, far higher than values shown by other fluoroquinolones such as norfloxacin (ratio 0.1) or ciprofloxacin (ratio 0.2). Ion trapping mechanisms were hypothesised to be among the determinants of this effect. However, whether ion trapping would solely account for the observed differences in fluoroquinolone pharmacokinetics was left to further research and discussion. In this hypothesis paper, we review various published evidence on the tissue distribution of moxifloxacin and other quinolones, suggesting that increased lipophilicity, binding to cellular matrices and fast cellular uptake/release kinetics may be mechanisms compatible with enhanced prostatic accumulation and secretion of fourth-generation fluoroquinolones. (C) 2008 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.



Zitierstile

Harvard-ZitierstilPerletti, G., Wagenlehner, F., Naber, K. and Magrid, V. (2009) Enhanced distribution of fourth-generation fluoroquinolones in prostatic tissue, International Journal of Antimicrobial Agents, 33(3), pp. 206-210. https://doi.org/10.1016/j.ijantimicag.2008.09.009

APA-ZitierstilPerletti, G., Wagenlehner, F., Naber, K., & Magrid, V. (2009). Enhanced distribution of fourth-generation fluoroquinolones in prostatic tissue. International Journal of Antimicrobial Agents. 33(3), 206-210. https://doi.org/10.1016/j.ijantimicag.2008.09.009



Schlagwörter


FLUOROQUINOLONEGatifloxacinGREPAFLOXACINJ774 MACROPHAGESLIPOPHILICITYMoxifloxacinMOXIFLOXACINPROSTATEprostatitisPROTONATION EQUILIBRIUMQUINOLONES CIPROFLOXACINSEMINAL FLUID


Nachhaltigkeitsbezüge


Zuletzt aktualisiert 2025-21-05 um 18:44