Journalartikel

Jahr der Veröffentlichung: 2008

Seiten: 677-682

Zeitschrift: Zeitschrift für Rheumatologie

Bandnummer: 67

Heftnummer: 8

ISSN: 0340-1855

eISSN: 1435-1250

DOI Link: https://doi.org/10.1007/s00393-008-0385-3

Verlag: Springer

Abstract: 
Amyloidoses make up a group of diseases caused by misfolded proteins. These misfolded proteins are insoluble and are deposited in various tissues and organs, ultimately resulting in severe organ dysfunction. The majority of patients with amlyoidoses suffer from chronic inflammatory, infectious or malignant diseases. Moreover, unexplained nephropathy, cardiomyopathy, neuropathy, enteropathy, arthropathy or macroglossia with or without periorbital bleeding should include an amyloidosis in the differential diagnosis. The latter is facilitated by histological examination of abdominal adipose tissue, the rectum or affected organs. Therapy focuses predominantly on reduction of activity of the underlying disease and specific organ protection. More recent therapeutic strategies include interleukin-1 inhibition, as well as inhibitors of protein misfolding.

Harvard-Zitierstil: Ladner-Merz, S. and Mueller-Ladner, U. (2008) Amyloidoses, Zeitschrift für Rheumatologie, 67(8), pp. 677-682. https://doi.org/10.1007/s00393-008-0385-3

APA-Zitierstil: Ladner-Merz, S., & Mueller-Ladner, U. (2008). Amyloidoses. Zeitschrift für Rheumatologie. 67(8), 677-682. https://doi.org/10.1007/s00393-008-0385-3