Konferenzpaper

Jahr der Veröffentlichung: 2008

Seiten: V44-V45

Zeitschrift: Rheumatology

Bandnummer: 47

ISSN: 1462-0324

Open Access Status: Bronze

DOI Link: https://doi.org/10.1093/rheumatology/ken309

Konferenz: Symposium on Controversies in Scleroderma

Verlag: Oxford University Press

Abstract: 
Skin thickening is a characteristic feature of SSc. More extensive skin involvement coincides with more severe internal organ manifestation(s), poor prognosis and increased disability, at least in the early phase of the diffuse cutaneous scleroderma subset. The fully validated, feasible method (gold standard) for measuring the dermal skin thickness is the modified Rodnan skin score (mRSS). The responsiveness of mRSS was somewhat modest in clinical trials, and a careful teaching process is necessary. Parallel method(s) for measuring skin thickness need to be used in the future. Ultrasound (US) measurement of the dermis with a 2030 MHz probe is a valid, reproducible and responsive method in patients with dcSSc. However, US is time-consuming and requires a training process. Of the mechanical instruments available, only the durometer, which measures the hardness of skin, has been validated. The inter- and intra-observer reproducibility and sensitivity to change of durometry were good, and correlated with mRSS and US-measured skin thickness. Several further mechanical instruments exist including the elastometer, twistometer, cutometer and plicometer. They seem to distinguish between involved and non-involved skin, and therefore merit further evaluation. The measurement of late-stage, irreversible skin damage/atrophy should be resolved in the future through the development and validation of new instruments.

Harvard-Zitierstil: Czirjak, L., Foeldvari, I. and Mueller-Ladner, U. (2008) Skin involvement in systemic sclerosis, Rheumatology, 47, pp. V44-V45. https://doi.org/10.1093/rheumatology/ken309

APA-Zitierstil: Czirjak, L., Foeldvari, I., & Mueller-Ladner, U. (2008). Skin involvement in systemic sclerosis. Rheumatology. 47, V44-V45. https://doi.org/10.1093/rheumatology/ken309