Journal article

Publication year: 2008

Pages: 594-602

Journal: Scandinavian Journal of Immunology

Volume number: 67

Issue number: 6

ISSN: 0300-9475

eISSN: 1365-3083

Open access status: Green

DOI Link: https://doi.org/10.1111/j.1365-3083.2008.02112.x

Publisher: Wiley

Abstract: 
Protection against intracellular pathogens is usually mediated by cytotoxic T lymphocytes (CTL). Induction of a protective CTL response for vaccination purposes has proven difficult because of the limited access of protein antigens or attenuated pathogens to the MHC class I presentation pathway. We show here that pH-sensitive PE/CHEMS liposomes can be used as a vehicle to efficiently deliver intact proteins for presentation by MHC class I. Mice immunized with listerial proteins encapsulated in such liposomes launched a strong CTL response and were protected against a subsequent challenge with L. monocytogenes. Remarkably, the CTL response was induced independently of detectable CD4(+) T cell help.

Harvard Citation style: Grenningloh, R., Darj, A., Bauer, H., zur Lage, S., Chakraborty, T., Jacobs, T., et al. (2008) Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4⁺ T cell help, Scandinavian Journal of Immunology, 67(6), pp. 594-602. https://doi.org/10.1111/j.1365-3083.2008.02112.x

APA Citation style: Grenningloh, R., Darj, A., Bauer, H., zur Lage, S., Chakraborty, T., Jacobs, T., & Weiss, S. (2008). Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4⁺ T cell help. Scandinavian Journal of Immunology. 67(6), 594-602. https://doi.org/10.1111/j.1365-3083.2008.02112.x