Journal article

Publication year: 2008

Pages: 257-270

Journal: Amino Acids

Volume number: 34

Issue number: 2

ISSN: 0939-4451

eISSN: 1438-2199

DOI Link: https://doi.org/10.1007/s00726-007-0497-0

Publisher: Springer

Abstract: 
We examined the effects of beta-alanine (taurine analogue and taurine transport antagonist), taurine (regarding its role in neutrophil (PMN) immunonutrition) and taurine combined either with L-NAME (inhibitor of center dot NO-synthase), SNAP (center dot NO donor), DON (glutamine-analogue and inhibitor of glutamine-requiring enzymes), DFMO (inhibitor of ornithine-decarboxylase) and beta-alanine on neutrophil amino- and alpha-keto acid profiles or important PMN immune functions in order to establish whether taurine transport-, nitric oxide-, glutamine- or ornithine-dependent mechanisms are involved in any of the taurine-induced effects. According to the present findings, the taurine-mediated effect appears to be based primarily on a modulation of important transmembraneous transport mechanisms and only secondarily on directly or indirectly induced modifications in intragranulocytic amino- and alpha-keto acid homoeostasis or metabolism. Although a direct relation to the parallel observed immunological modifications can only be presumed, these results show very clearly that compositional modifications in the free intragranulocytic amino- and alpha keto-acid pools coinciding with changes in intragranulocytic taurine levels are relevant metabolic determinants that can significantly influence the magnitude and quality of the granulocytic immune response.

Harvard Citation style: Muelling, J., Nickolaus, K., Matejec, R., Langefeld, T., Harbach, H., Engel, J., et al. (2008) Which mechanisms are involved in taurine-dependent granulocytic immune response or amino- and α-keto acid homeostasis?, Amino Acids, 34(2), pp. 257-270. https://doi.org/10.1007/s00726-007-0497-0

APA Citation style: Muelling, J., Nickolaus, K., Matejec, R., Langefeld, T., Harbach, H., Engel, J., Wolff, M., Weismueller, K., Fuchs, M., Welters, I., Kruell, M., Heidt, M., & Hempelmann, G. (2008). Which mechanisms are involved in taurine-dependent granulocytic immune response or amino- and α-keto acid homeostasis?. Amino Acids. 34(2), 257-270. https://doi.org/10.1007/s00726-007-0497-0