Journal article

Publication year: 2007

Pages: 511-524

Journal: Amino Acids

Volume number: 33

Issue number: 3

ISSN: 0939-4451

eISSN: 1438-2199

DOI Link: https://doi.org/10.1007/s00726-006-0395-x

Publisher: Springer

Abstract: 
We examined the effects of DON [glutamine-analogue and inhibitor of glutamine-requiring enzymes], alanyl-glutamine (regarding its role in neutrophil immunonutrition) and alanyl-glutamine combined with L-NAME, SNAP, DON, beta-alanine and DFMO on neutrophil amino and alpha-keto acid concentrations or important neutrophil immune functions in order to establish whether an inhibitor of .NO-synthase [L-NAME], an .NO donor [SNAP], an analogue of taurine and a taurine transport antagonist [beta-alanine], an inhibitor of ornithine-decarboxylase [DFMO] as well as DON could influence any of the alanyl-glutamine-induced effects. In summary, irrespective of which pharmacological, metabolism-inhibiting or receptor-mediated mechanisms were involved, our results showed that impairment of granulocytic glutamine uptake, modulation of intracellular glutamine metabolisation and/or de novo synthesis as well as a blockade of important glutamine-dependent metabolic processes may led to significant modifications of physiological and immunological functions of the affected cells.

Harvard Citation style: Muehling, J., Burchert, D., Langefeld, T., Matejec, R., Harbach, H., Engel, J., et al. (2007) Pathways involved in alanyl-glutamine-induced changes in neutrophil amino- and α-keto acid homeostasis or immunocompetence, Amino Acids, 33(3), pp. 511-524. https://doi.org/10.1007/s00726-006-0395-x

APA Citation style: Muehling, J., Burchert, D., Langefeld, T., Matejec, R., Harbach, H., Engel, J., Wolff, M., Welters, I., Fuchs, M., Menges, T., Kruell, M., & Hempelmann, G. (2007). Pathways involved in alanyl-glutamine-induced changes in neutrophil amino- and α-keto acid homeostasis or immunocompetence. Amino Acids. 33(3), 511-524. https://doi.org/10.1007/s00726-006-0395-x