Journal article

Publication year: 2007

Pages: 729-734

Journal: Journal of Neurology

Volume number: 254

Issue number: 6

ISSN: 0340-5354

DOI Link: https://doi.org/10.1007/s00415-006-0411-9

Publisher: Springer

Abstract: 

Several case reports have linked iron deficiency anemia with the occurrence of cerebral venous thrombosis (CVT) or stroke, yet, it is unclear whether this is a chance association.

In a case-control design data of whole blood count and screening for thrombophilic coagulation abnormalities of 121 prospectively identified patients with CVT and 120 healthy controls were compared. Anemia was defined as a hemoglobin (Hb) concentration of < 120 g/l in females, and < 130 g/l in males, severe anemia as a Hb < 90 g/l. Adjusted odds ratios (OR) were calculated based on a logistic regression model treating variables with a level of significance of p <= 0.2 on univariate analysis as potential confounders.

Thrombophilia (OR 1.22, 95% CI 1.07-1.76, p < 0.01), severe anemia (OR 1.10, 95% CI 1.01-2.22, p < 0.05), and hypercholesterinemia (OR 1.21, 95% CI 1.04-2.57, p < 0.05) were the only independent variables associated with CVT on multivariate analysis.

Severe anemia is significantly and independently associated with CVT.

Harvard Citation style: Stolz, E., Valdueza, J., Grebe, M., Schlachetzki, F., Schmitt, E., Madlener, K., et al. (2007) Anemia as a risk factor for cerebral venous thrombosis? An old hypothesis revisited, Journal of Neurology, 254(6), pp. 729-734. https://doi.org/10.1007/s00415-006-0411-9

APA Citation style: Stolz, E., Valdueza, J., Grebe, M., Schlachetzki, F., Schmitt, E., Madlener, K., Rahimi, A., Kempkes-Matthes, B., Blaes, F., Gerriets, T., & Kaps, M. (2007). Anemia as a risk factor for cerebral venous thrombosis? An old hypothesis revisited. Journal of Neurology. 254(6), 729-734. https://doi.org/10.1007/s00415-006-0411-9