Conference paper

Publication year: 2007

Pages: 2286-2289

Journal: Life Sciences

Volume number: 80

Issue number: 24-25

ISSN: 0024-3205

DOI Link: https://doi.org/10.1016/j.lfs.2007.01.043

Conference: 2nd International Symposium on Non-Neuronal Acetylcholine

Publisher: Elsevier

Abstract: 
The success of clinical lung transplantation is poor in comparison to other solid organ transplants and novel therapeutic approaches are badly needed. In the view of the recent discovery of anti-inflammatory pathways mediated via nicotinic acetylcholine receptors, we investigated changes in this system in pulmonary isografts and allografts by immunohistochemistry. Lung transplantation was performed in the isogeneic Lewis to Lewis rat strain combination. For allogeneic transplantation Dark Agouti rats were used as donors. Nicotinic alpha 9 and alpha 10 acetylcholine receptor subunits were detected on alveolar macrophages as well as in the lung parenchyma of native and transplanted lungs. The expression of both receptor subunits was up-regulated in the parenchyma of day 4 allografts. These allografts were characterized by accumulations of alveolar macrophages strongly expressing the a9 and the (alpha 10 receptor subunit. Therapeutic application of nicotinic agonists might down-modulate proinflammatory functions of alveolar macrophages and protect pulmonary transplants. (c) 2007 Elsevier Inc. All rights reserved.

Harvard Citation style: Biallas, S., Wilker, S., Lips, K., Kummer, W., Grando, S., Padberg, W., et al. (2007) Immunohistochemical detection of nicotinic acetylcholine receptor subunits α9 and α10 in rat lung isografts and allografts, Life Sciences, 80(24-25), pp. 2286-2289. https://doi.org/10.1016/j.lfs.2007.01.043

APA Citation style: Biallas, S., Wilker, S., Lips, K., Kummer, W., Grando, S., Padberg, W., & Grau, V. (2007). Immunohistochemical detection of nicotinic acetylcholine receptor subunits α9 and α10 in rat lung isografts and allografts. Life Sciences. 80(24-25), 2286-2289. https://doi.org/10.1016/j.lfs.2007.01.043