Journal article

Publication year: 2007

Pages: 446-450

Journal: Der Orthopäde

Volume number: 36

Issue number: 5

ISSN: 0085-4530

eISSN: 1433-0431

DOI Link: https://doi.org/10.1007/s00132-007-1084-5

Publisher: Springer

Abstract: 
Avascular necrosis (AVN) of the hip is one of the unsolved problems in orthopedics, especially with regard to drug therapy. Only a few studies exist using a long-term approach with vasodilating agents such as prostaglandins, anticoagulants, hormones, as well as lipid lowering and bone protective drugs such as bisphosphonates. However, using these medications several studies have demonstrated a significant reduction in pain, in the destruction of the femoral head as well as in overall disability. This resulted in a reduced need for joint replacement in patients with AVN and to a substantial improvement in quality of life. Of note, drug therapy should be initiated in the early phases of AVN as later stages appear to be less responsive to medication.

Harvard Citation style: Tarner, I., Dinser, R. and Mueller-Ladner, U. (2007) Pharmacotherapeutic aspects of femoral head necrosis, Orthopäde, 36(5), pp. 446-450. https://doi.org/10.1007/s00132-007-1084-5

APA Citation style: Tarner, I., Dinser, R., & Mueller-Ladner, U. (2007). Pharmacotherapeutic aspects of femoral head necrosis. Orthopäde. 36(5), 446-450. https://doi.org/10.1007/s00132-007-1084-5