Journal article

Publication year: 2007

Journal: Arthritis Research and Therapy

Volume number: 9

Issue number: 6

ISSN: 1478-6354

eISSN: 1478-6362

Open access status: Gold

DOI Link: https://doi.org/10.1186/ar2337

Publisher: BioMed Central

Abstract: 
For some time synovial fibroblasts have been regarded simply as innocent synovial cells, mainly responsible for synovial homeostasis. During the past decade, however, a body of evidence has accumulated illustrating that rheumatoid arthritis synovial fibroblasts (RASFs) are active drivers of joint destruction in rheumatoid arthritis. Details regarding the intracellular signalling cascades that result in long-term activation and synthesis of proinflammatory molecules and matrix-degrading enzymes by RASFs have been analyzed. Molecular, cellular and animal studies have identified various interactions with other synovial and inflammatory cells. This expanded knowledge of the distinct role played by RASFs in the pathophysiology of rheumatoid arthritis has moved these fascinating cells to the fore, and work to identify targeted therapies to inhibit their joint destructive potential is underway.

Harvard Citation style: Mueller-Ladner, U., Ospelt, C., Gay, S., Distler, O. and Pap, T. (2007) Cells of the synovium in rheumatoid arthritis -: Synovial fibroblasts, Arthritis Research and Therapy, 9(6), Article 223. https://doi.org/10.1186/ar2337

APA Citation style: Mueller-Ladner, U., Ospelt, C., Gay, S., Distler, O., & Pap, T. (2007). Cells of the synovium in rheumatoid arthritis -: Synovial fibroblasts. Arthritis Research and Therapy. 9(6), Article 223. https://doi.org/10.1186/ar2337