Journalartikel
Autorenliste: Popov, Alexey; Abdullah, Zeinab; Wickenhauser, Claudia; Saric, Tomo; Driesen, Julia; Hanisch, Franz-Georg; Domann, Eugen; Raven, Emma Lloyd; Dehus, Oliver; Hermann, Corinna; Eggle, Daniela; Debey, Svenja; Chakraborty, Trinad; Kroenke, Martin; Utermoehlen, Olaf; Schultze, Joachim L.
Jahr der Veröffentlichung: 2006
Seiten: 3160-3170
Zeitschrift: The Journal of Clinical Investigation
Bandnummer: 116
Heftnummer: 12
ISSN: 0021-9738
Open Access Status: Green
DOI Link: https://doi.org/10.1172/JCI28996
Verlag: American Society for Clinical Investigation
Abstract:
Control of pathogens by formation of abscesses and granulomas is a major strategy of the innate immune system, especially when effector mechanisms of adaptive immunity are insufficient. We show in human listeriosis that DCs expressing indoleamine 2,3-dioxygenase (IDO), together with macrophages, are major cellular components of suppurative granulomas in vivo. Induction of IDO by DCs is a cell-autonomous response to Listeria monocytogenes infection and was also observed in other granulomatous infections with intracelhilar bacteria, such as Bartonella benselae. Reporting on our use of the clinically applied anti-TNF-alpha antibody infliximab, we further demonstrate in vitro that IDO induction is TNF-alpha dependent. Repression of IDO therefore might result in exacerbation of granulomatous diseases observed during anti-TNF-a therapy. These findings place IDO+ DCs not only at the intersection of innate and adaptive immunity but also at the forefront of bacterial containment in gramilomatous infections.
Zitierstile
Harvard-Zitierstil: Popov, A., Abdullah, Z., Wickenhauser, C., Saric, T., Driesen, J., Hanisch, F., et al. (2006) Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection, The Journal of Clinical Investigation, 116(12), pp. 3160-3170. https://doi.org/10.1172/JCI28996
APA-Zitierstil: Popov, A., Abdullah, Z., Wickenhauser, C., Saric, T., Driesen, J., Hanisch, F., Domann, E., Raven, E., Dehus, O., Hermann, C., Eggle, D., Debey, S., Chakraborty, T., Kroenke, M., Utermoehlen, O., & Schultze, J. (2006). Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection. The Journal of Clinical Investigation. 116(12), 3160-3170. https://doi.org/10.1172/JCI28996
Schlagwörter
BACTERIAL-INFECTION; COLONY-STIMULATING FACTOR; FACTOR-ALPHA; GAMMA-INTERFERON; LIPOTEICHOIC ACID; MONONUCLEAR PHAGOCYTES; MYCOBACTERIUM-TUBERCULOSIS
