Journalartikel
Autorenliste: Ehling, Angela; Schaeffler, Andreas; Herfarth, Hans; Tarner, Ingo H.; Anders, Sven; Distler, Oliver; Paul, Gisela; Distler, Joerg; Gay, Steffen; Schoelmerich, Jurgen; Neumann, Elena; Mueller-Ladner, Ulf
Jahr der Veröffentlichung: 2006
Seiten: 4468-4478
Zeitschrift: The Journal of Immunology
Bandnummer: 176
Heftnummer: 7
ISSN: 0022-1767
eISSN: 1550-6606
Open Access Status: Bronze
DOI Link: https://doi.org/10.4049/jimmunol.176.7.4468
Verlag: American Association of Immunologists
Abstract:
Articular adipose tissue is a ubiquitous component of human joints, but its local functions are largely unknown. Because recent studies revealed several links between adipose tissue, adipocytokines, and arthritis, we investigated the expression of the adipocytokine adiponectin and its functional role in articular adipose tissue and synovium of patients with different arthritides. In contrast to its protective role in endocrinological and vascular diseases, adiponectin was found to be involved in key pathways of inflammation and matrix degradation in the human joint. The effects of adiponectin in human synovial fibroblasts appear to be highly selective by inducing only two of the main mediators of rheumatoid arthritis pathophysiology, IL-6 and matrix metalloproteinase-1, via the p38 MAPK pathway. Owing to the observation that these effects could be inhibited by different TNF-alpha inhibitors, adipocytokines such as adiponectin may also be key targets for therapeutic strategies in inflammatory joint diseases. In summary, articular adipose tissue and adipocytokines cannot be regarded as innocent bystanders any more in chronic inflammatory diseases such as arthritis.
Zitierstile
Harvard-Zitierstil: Ehling, A., Schaeffler, A., Herfarth, H., Tarner, I., Anders, S., Distler, O., et al. (2006) The potential of adiponectin in driving arthritis, The Journal of Immunology, 176(7), pp. 4468-4478. https://doi.org/10.4049/jimmunol.176.7.4468
APA-Zitierstil: Ehling, A., Schaeffler, A., Herfarth, H., Tarner, I., Anders, S., Distler, O., Paul, G., Distler, J., Gay, S., Schoelmerich, J., Neumann, E., & Mueller-Ladner, U. (2006). The potential of adiponectin in driving arthritis. The Journal of Immunology. 176(7), 4468-4478. https://doi.org/10.4049/jimmunol.176.7.4468
Schlagwörter
INFLAMMATORY CYTOKINES; MATRIX METALLOPROTEINASES; PLASMA-PROTEIN; RHEUMATOID-ARTHRITIS; synovial fibroblasts
