Journalartikel

Jahr der Veröffentlichung: 2005

Seiten: 543-548

Zeitschrift: Journal of Perinatal Medicine

Bandnummer: 33

Heftnummer: 6

ISSN: 0300-5577

eISSN: 1619-3997

DOI Link: https://doi.org/10.1515/JPM.2005.097

Verlag: De Gruyter Brill

Abstract: 
Status and school achievement of 129 children born in Hessen between 1988 and 1992 and notified by a repeatedly elevated concentration of TSH in neonatal screening were evaluated. Interviews of mothers, teachers and pediatricians were used to score the development and educational achievements, respectively. A total of 298,175 newborns were screened and the incidence of permanent congenital hypothyroidism (PCH) was 1: 3,313 (n=90). The female/male ratio was 1.37: 1. In the 69 PCH cases with complete data, athyreosis (52%), hypoplasia (32%), dyshormogenesis (9%) and ectopia (7%) were identified as etiologies. The mean age at start of therapy decreases from day 15 in 1988 to day 9 in 1992; however, 27% of PCH children showed reduced psychomotor development as scored by their pediatrician and 11% attended a special school for educationally subnormal children. Approximately 25% of the children had lower educational achievements irrespective of the school type. Our finding of a relatively high percentage of PCH children with subnormal development points to a failure in disease management. A follow-up program including repeated serum TSH monitoring and yearly examinations by pediatric endocrinologists and supervision by the regional screening center is necessary to ensure the long-term efficacy of neonatal screening for congenital hypothyroidism.

Harvard-Zitierstil: Höpfner, S., Höpfner, B. and Rauterberg, E. (2005) Neonatal screening for congenital hypothyroidism in Hessen, Germany:: efficiency of the screening program and school achievement of 129 children at an age of 8-12 years, Journal of Perinatal Medicine, 33(6), pp. 543-548. https://doi.org/10.1515/JPM.2005.097

APA-Zitierstil: Höpfner, S., Höpfner, B., & Rauterberg, E. (2005). Neonatal screening for congenital hypothyroidism in Hessen, Germany:: efficiency of the screening program and school achievement of 129 children at an age of 8-12 years. Journal of Perinatal Medicine. 33(6), 543-548. https://doi.org/10.1515/JPM.2005.097