Journal article

Publication year: 2005

Pages: 289-300

Journal: Amino Acids

Volume number: 29

Issue number: 3

ISSN: 0939-4451

eISSN: 1438-2199

DOI Link: https://doi.org/10.1007/s00726-005-0223-8

Publisher: Springer

Abstract: 
The objective of this study was to determine the dose as well as duration of exposure-dependent effects of L-alanyl-L-glutamine, arginine or taurine on polymorphonuclear neutrophil (PMN) free alpha-keto acid profiles and, in a parallel study, on PMN immune functions. Exogenous L-alanyl-L-glutamine significantly increased PMN alpha-ketoglutarate, pyruvate PMN superoxide anion (O-2(-)) generation, hydrogen peroxide (H2O2) formation and released myeloperoxidase (MPO) activity. Arginine also led to significant increases in alpha-ketoglutarate, pyruvate, MPO release and H2O2 generation. Formation of O-2(-) on the other hand was decreased by arginine. Incubation with taurine resulted in lower intracellular pyruvate and alpha-ketobutyrate levels, decreased O-2(-) and H2O2 formation and a concomitant significantly increased MPO activity. We therefore believe that considerable changes in PMN free-alpha-keto-acid profiles, induced for example by L-alanyl-L-glutamine, arginine or taurine, may be one of the determinants in cell nutrition that considerably modulates the immunological competence of PMN.

Harvard Citation style: Mühling, J., Nickolaus, K., Halabi, M., Fuchs, M., Krüll, M., Engel, J., et al. (2005) Alterations in neutrophil (PMN) free intracellular alpha-keto acid profiles and immune functions induced by L-alanyl-L-glutamine, arginine or taurine, Amino Acids, 29(3), pp. 289-300. https://doi.org/10.1007/s00726-005-0223-8

APA Citation style: Mühling, J., Nickolaus, K., Halabi, M., Fuchs, M., Krüll, M., Engel, J., Wolff, M., Matejec, R., Langefeld, T., Welters, I., Menges, T., Dehne, M., Sablotzki, A., & Hempelmann, G. (2005). Alterations in neutrophil (PMN) free intracellular alpha-keto acid profiles and immune functions induced by L-alanyl-L-glutamine, arginine or taurine. Amino Acids. 29(3), 289-300. https://doi.org/10.1007/s00726-005-0223-8