Journal article

Publication year: 2005

Pages: 399-417

Journal: Archivum Immunologiae et Therapiae Experimentalis

Volume number: 53

Issue number: 5

ISSN: 0004-069X

eISSN: 1661-4917

Publisher: Sciendo

Abstract: 
Surfactant proteins A (SP-A) and D (SP-D) are lung surfactant-associated hydrophilic proteins that have been implicated in surfactant homeostasis and pulmonary innate immunity. They are collagen-containing C-type (calcium-dependent) lectins, called collectins, and are structurally similar to mannose-binding protein of the lectin pathway of the complement system. Being carbohydrate pattern-recognition molecules, they recognize a broad spectrum of pathogens and allergens via the lectin domain, with subsequent activation of immune cells via the collagen region, thus offering protection against infection and allergenic challenge. SP-A and SP-D have been shown to be involved in viral neutralization, clearance of bacteria, fungi, and apoptotic and necrotic cells, down-regulation of allergic reaction, and resolution of inflammation. Studies on single-nucleotide polymorphism, protein levels in broncho-alveolar lavage, and gene knock-out mice have clearly indicated an association between SP-A and SP-D and a range of pulmonary diseases. In addition, recent studies using murine models of allergy and infection have raised the possibility that the recombinant forms of SP-A and SP-D may have therapeutic potential in controlling pulmonary infection, inflammation, and allergies in humans.

Harvard Citation style: Kishore, U., Bernal, A., Kamran, M., Saxena, S., Singh, M., Sarma, P., et al. (2005) Surfactant proteins SP-A and SP-D in human health and disease, Archivum Immunologiae et Therapiae Experimentalis, 53(5), pp. 399-417

APA Citation style: Kishore, U., Bernal, A., Kamran, M., Saxena, S., Singh, M., Sarma, P., Madan, T., & Chakraborty, T. (2005). Surfactant proteins SP-A and SP-D in human health and disease. Archivum Immunologiae et Therapiae Experimentalis. 53(5), 399-417.