Journalartikel

Jahr der Veröffentlichung: 2005

Seiten: 85-98

Zeitschrift: Amino Acids

Bandnummer: 28

Heftnummer: 1

ISSN: 0939-4451

eISSN: 1438-2199

DOI Link: https://doi.org/10.1007/s00726-004-0136-y

Verlag: Springer

Abstract: 
We have examined the effects of midazolam, Ro 5-4864 (agonist for "peripheral'' [p] benzodiazepine receptors [BR]), PK 11195 ( antagonist for pBR), flumazenil ( antagonist for "central'' BR), naloxone ( antagonist for opiate receptors) and the combination of midazolam and Ro 5-4864, PK 11195, flumazenil or naloxone on intracellular amino- and alpha-keto acids and the immune function markers superoxide anion (O-2(-)), hydrogen peroxide (H2O2) and released myeloperoxidase (MPO) activity in neutrophils (PMN). Only midazolam and Ro 5-4864 led to significant changes in the dynamic PMN free amino- and alpha-keto acid pools. Concerning PMN immune function markers, midazolam and Ro 5-4864 significantly decreased O-2(-) and H2O2 formation and released MPO. When midazolam and Ro 5-4864 were applied together they appeared to act additively. Pre-incubation with PK 11195 partially neutralized the midazolam effects whereas flumazenil or naloxone showed no effects. We therefore believe that pBR are involved in the signal transmission of anesthetic-induced cellular metabolic changes in PMN.

Harvard-Zitierstil: Mühling, J., Gonter, J., Nickolaus, K., Matejec, R., Welters, I., Wolff, M., et al. (2005) Benzodiazepine receptor-dependent modulation of neutrophil (PMN) free amino- and α-keto acid profiles or immune functions, Amino Acids, 28(1), pp. 85-98. https://doi.org/10.1007/s00726-004-0136-y

APA-Zitierstil: Mühling, J., Gonter, J., Nickolaus, K., Matejec, R., Welters, I., Wolff, M., Sablotzki, A., Engel, J., Krüll, M., Menges, T., Fuchs, M., Dehne, M., & Hempelmann, G. (2005). Benzodiazepine receptor-dependent modulation of neutrophil (PMN) free amino- and α-keto acid profiles or immune functions. Amino Acids. 28(1), 85-98. https://doi.org/10.1007/s00726-004-0136-y