Journalartikel

Jahr der Veröffentlichung: 2004

Seiten: 282-289

Zeitschrift: Biomedical Engineering

Bandnummer: 49

Heftnummer: 10

ISSN: 0013-5585

eISSN: 1862-278X

Verlag: De Gruyter Brill

Abstract: 
This study analyzes the qualification of biochemical markers in the diagnosis of osteoporosis and evaluates the potential of a multiparametric classification of premenopausal and non-osteoporotic as well as osteoporotic postmenopausal women, which is based on biochemical marker profiles. For this evaluation data of 29 women in the age between 28-74 years were used. The classification of osteoporosis was done by the trabecular density of the lumbar spine using qCT-measurements. The biochemical markers of formation and resorption AP, bAP, OC, ucOC, PICP, PYD, DPD, NTX, BSP and vitamin K were analyzed on day 1 and 42 in all patients. For vitamin K we found significant distribution differences between non-osteoporotic and osteoporotic women (p<0.005). The crosslinks PYD and DPD showed weakly significant differences. All other parameters exhibited non-significant results. Vitamin K acted with a sensitivity of 64% and a specificity of 82%. The used multiparameter classification process improved sensitivity and specificity considerably. The parameter profiles of OC/PYD, vitamin K/PYD and vitamin K/bAP revealed the highest sensitivities with specificities of more than 82%.

Harvard-Zitierstil: Heiss, C., Keller, T., Wehr, U., Mohr, A., Lommel, D., Meyer, C., et al. (2004) Biochemical markers and their significance in postmenopausal osteoporosis - A new method in the diagnosis of osteoporosis?, Biomedical Engineering, 49(10), pp. 282-289

APA-Zitierstil: Heiss, C., Keller, T., Wehr, U., Mohr, A., Lommel, D., Meyer, C., Rambeck, W., & Schnettler, R. (2004). Biochemical markers and their significance in postmenopausal osteoporosis - A new method in the diagnosis of osteoporosis?. Biomedical Engineering. 49(10), 282-289.