Journal article

Publication year: 2004

Pages: 89-93

Journal: NeuroReport

Volume number: 15

Issue number: 1

ISSN: 0959-4965

eISSN: 1473-558X

DOI Link: https://doi.org/10.1097/01.wnr.0000103270.91211.a1

Publisher: Lippincott, Williams & Wilkins

Abstract: 
Estrogen treatment in symptomatic postmenopausal women appears to improve cognitive performance including memory, an effect which may involve enhanced nitric oxide formation in hippocampal neurons. To study whether 17beta-estradiol (E2) affects NO synthase activity in the hippocampus, we investigated the influence of E2 on hippocampal NO synthase expression and activity in female rats. Ovariectomy, which significantly decreased E2 serum levels, reduced neuronal (nNOS) and endothelial NO synthase (eNOS) expression and Ca2+-dependent NOS activity. E2 substitution reversed these effects. It is concluded that E2 increases nNOS and eNOS expression and activity in female hippocampus and thus improves hippocampal function.

Harvard Citation style: Grohé, C., Kann, S., Fink, L., Djoufack, P., Paehr, M., van Eickels, M., et al. (2004) 17β-estradiol regulates nNOs and eNOS activity in the hippocampus, NeuroReport, 15(1), pp. 89-93. https://doi.org/10.1097/01.wnr.0000103270.91211.a1

APA Citation style: Grohé, C., Kann, S., Fink, L., Djoufack, P., Paehr, M., van Eickels, M., Vetter, H., Meyer, R., & Fink, K. (2004). 17β-estradiol regulates nNOs and eNOS activity in the hippocampus. NeuroReport. 15(1), 89-93. https://doi.org/10.1097/01.wnr.0000103270.91211.a1