Journal article
Authors list: Hauck, EW; Hauptmann, A; Weidner, W; Bein, G; Hackstein, H
Publication year: 2003
Pages: 1443-1446
Journal: The Journal of Urology
Volume number: 170
Issue number: 4
ISSN: 0022-5347
eISSN: 1527-3792
DOI Link: https://doi.org/10.1097/01.ju.0000076488.89748.e1
Publisher: Lippincott, Williams & Wilkins
Purpose: The pathogenesis of Peyronie's disease remains unclear. Previous studies have described possible associations among various HLAs and Peyronie's disease. However, only small series comprising 9 to 52 patients were analyzed in these studies and published results are controversial. We prospectively investigated a possible association of Peyronie's disease with HLA classes I and II specificity in a large patient group. Materials and Methods: A total of 154 consecutive patients with Peyronie's disease were typed serologically for HLA class I antigens. Molecular typing of HLA class II alleles was performed by polymerase chain reaction sequence specific primers. Results were compared with those in healthy bone marrow donors for HLA classes I (2,450) and II (316), serving as representative controls selected from the local population. In addition, HLA distribution in a German normal cohort of 14,835 individuals served as a control. Results: No significant difference in HLA classes I and II antigen frequency was evident in patients with Peyronie's disease compared with healthy controls. Conclusions: The results of this study do not indicate any significant association between Peyronie's disease and antigens of the HLA system.
Abstract:
Citation Styles
Harvard Citation style: Hauck, E., Hauptmann, A., Weidner, W., Bein, G. and Hackstein, H. (2003) Prospective analysis of HLA classes I and II antigen frequency in patients with Peyronie's disease, The Journal of Urology, 170(4), pp. 1443-1446. https://doi.org/10.1097/01.ju.0000076488.89748.e1
APA Citation style: Hauck, E., Hauptmann, A., Weidner, W., Bein, G., & Hackstein, H. (2003). Prospective analysis of HLA classes I and II antigen frequency in patients with Peyronie's disease. The Journal of Urology. 170(4), 1443-1446. https://doi.org/10.1097/01.ju.0000076488.89748.e1
Keywords
CROSS-REACTIVE ANTIGENS; ETIOLOGY; HLA antigens; penile induration; penis
