Journal article

Publication year: 2003

Pages: 532-537

Journal: Acta Radiologica

Volume number: 44

Issue number: 5

ISSN: 0284-1851

DOI Link: https://doi.org/10.1034/j.1600-0455.2003.00113.x

Publisher: SAGE Publications

Abstract: 

Purpose: To evaluate micro computed tomography (micro-CT) for the assessment of osteochondritis dissecans in comparison with histology.

Material and Methods: Osteochondritis dissecans lesions of 3 patients were evaluated using micro-CT (0.125 mA, 40 keV, 60 mum slice thickness, 60 mum isotropic resolution, entire sample) and light microscopy (toluidine blue, 3-5 mum slice thickness). The methods were compared regarding preparation time, detectability of tissue types and morphologic features of bone and cartilage.

Results: Non-destructive micro-CT imaging of the entire sample was faster than histologic preparation of a single slice for light microscopy. Morphologic features of bone and cartilage could be imaged in a comparable way to histology. It was not possible to image cells or different tissue types of bone and cartilage with micro-CT.

Conclusion: Micro-CT is a fast, non-destructive tool that may be a supplement or, if detailed histologic information is not necessary, an alternative to light microscopy for the investigation of osteochondritis dissecans.

Harvard Citation style: Mohr, A., Heiss, C., Bergmann, I., Schrader, C., Roemer, F., Lynch, J., et al. (2003) Value of micro-CT as an investigative tool for osteochondritis dissecans - A preliminary study with comparison to histology, Acta Radiologica, 44(5), pp. 532-537. https://doi.org/10.1034/j.1600-0455.2003.00113.x

APA Citation style: Mohr, A., Heiss, C., Bergmann, I., Schrader, C., Roemer, F., Lynch, J., Muhle, C., Genant, H., & Heller, M. (2003). Value of micro-CT as an investigative tool for osteochondritis dissecans - A preliminary study with comparison to histology. Acta Radiologica. 44(5), 532-537. https://doi.org/10.1034/j.1600-0455.2003.00113.x