Journal article

Publication year: 2003

Pages: 164-171

Journal: Aktuelle Rheumatologie

Volume number: 28

Issue number: 3

ISSN: 0341-051X

eISSN: 1438-9940

Publisher: Georg Thieme Verlag

Abstract: 
This study analyses the potential of a multiparametric assessment of biochemical marker profiles to differentiate between premenopausal, postmenopausal non-osteoporotic and osteoporotic women. Data of women aged between 28 to 74 years were used for this evaluation. The rating of the groups was done by the T-Score of the QCT measurement. The biochemical markers of formation and resorption: AP, BAP, OC, ucOC, PICP, PYD, DPD, BSP, NTX and vitamin K were analysed at day 1 and 42 in all patients. For vitamin K we found significant distribution differences and differences in tendency for the crosslinks (DPD and PYD). In the ROC analysis vitamin K attained the highest AUC score of 0.86. The combinations of vitamin K and PICR AP, BAR ucOC, OC, BSP and NTX had the highest AUC scores (0.85-0.99). The multiparameter classification processes showed high sensitivity and specificity levels. The parameter combinations of vitamin K/PYD, vitamin K/BAP and OC/PYD revealed the highest sensitivity values with specificities of more than 82%.

Harvard Citation style: Heiss, C., Keller, T., Wehr, U., Pauschl, M., Horas, U., Kilian, O., et al. (2003) The assessment of biochemical marker profiles in diagnosis of osteoporosis, Aktuelle Rheumatologie, 28(3), pp. 164-171

APA Citation style: Heiss, C., Keller, T., Wehr, U., Pauschl, M., Horas, U., Kilian, O., Rambeck, W., & Schnettler, R. (2003). The assessment of biochemical marker profiles in diagnosis of osteoporosis. Aktuelle Rheumatologie. 28(3), 164-171.